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Iranian Journal of Public Health، جلد ۳۷، شماره sup، صفحات ۱۶-۲۲
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عنوان انگلیسی Severity of Coronary Artery Involvement Correlates with Bone Turnover
چکیده انگلیسی مقاله Background: To evaluate bone turnover in coronary artery disease patients by using biochemical markers of bone forma­tion and resorption. Methods: As a cross-sectional study, bone mineral density and serum osteocalcin and crosslaps were measured in 44 an­giographically documented coronary artery disease patients and 30 people with normal angiography invited to Endocrinol­ogy and Metabolism Research Center. Results: Bone mineral density of femur was significantly lower in patient with coronary artery disease ( P = 0.04). Preva­lence of femur osteoporosis in patients with coronary artery disease was 43.2% whereas 14.8% of people with normal an­giography had femur osteoporosis ( P = 0.01, OR= 4.37; CI95%, 1.29-14, 77).Serum level of osteocalcin and crosslaps ele­vated significantly with increasing severity of coronary artery disease. A significantly positive correlation was found be­tween coronary artery disease severity and serum level of osteocalcin ( P = 0.008, r= 0.320). Crosslaps also showed similar cor­relation with number of diseased vessels ( P = 0.02, r= 0.268). In multivariate analysis after adjustment of age, sex and BMI, severity of coronary artery disease was independently correlated with osteocalcin ( P = 0.006) and crosslaps ( P = 0.003). Conclusion: It seems that coronary artery disease and severity of atherosclerosis may be as a bone turnover predictor. Thus rec­ommendation of Bone density and turnover evaluation to patients with a coronary event may be valuable for earlier di­agnosis and prevention of osteoporosis and fracture.
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نویسندگان مقاله m جعفر محمودی | m jafar mahmoodi
dept. of cardiology, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

h ثقفی | h saghafi
endocrinology and metabolism research center of tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

f کریمی | f karimi
endocrinology and metabolism research center of tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

h بهزادی | h behzadi
endocrinology and metabolism research center of tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

b لاریجانی | b larijani
endocrinology and metabolism research center of tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/2893
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