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Iranian Journal of Public Health، جلد ۳۶، شماره ۴، صفحات ۸۷-۹۰

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عنوان انگلیسی The Short-Term Effects of Sulfur Mustard Gas on the Complement System
چکیده انگلیسی مقاله Background: The serum levels of C 3 , C4, and the total hemolytic activity of complement system (CH50) of patients ex­posed to mustard gas (MG) in the battlefield were measured in this study. Methods: C3 and C4 were measured by single radial immunodifusion and CH50 was evaluated according to total hemolytic activ­ity of the serum. Results: The serum levels of C 3 showed a significant increase on day 3 after exposure to MG. The serum levels of C 3 in the sera of patients collected during 4-18 and 19-31 days after exposure to MG were also found to have increased significantly com­paring to those of the controls. The levels of C 4 in the sera of patients collected from the patients during 4-18 and 19-31 days after exposure were also found to be significantly higher than those of the controls. However the increase in the serum lev­els of C 4 were not in the same magnitude as those of the C 3 . The serum CH50, which is a measure of the total hemolytic activ­ity of classical complement system also showed a significant increase in patients' sera on day 3 and in the sera collected dur­ing 4-18 days after exposure. However, the CH50 in the sera of patients showed a decrease in the sera collected during 19-31 days after exposure to MG. Conclusion: Since C3 is an acute phase protein as well as a complement component, these results are discussed in terms of a vigorous acute phase response and activation of the complement system.
کلیدواژه‌های انگلیسی مقاله C3, C4, CH50

نویسندگان مقاله ah کیهانی | ah keyhani


mr نوروزی | mr nowroozi



نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/2096
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