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Physiology and Pharmacology، جلد ۲۱، شماره ۳، صفحات ۲۴۱-۲۵۰
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عنوان انگلیسی Effect of tempol, a synthetic antioxidant, on renal complications of L-NAME induced preeclampsia in rat
چکیده انگلیسی مقاله Introduction: It has been suggested that oxidative stress has a crucial role in the pathophysiology of preeclampsia. In the present study, the effect of tempol, a synthetic antioxidant, on kidney injuries and oxidative stress was investigated in an experimental model of preeclampsia in rats. Methods: Preeclampsia was induced by oral administration of L-NAME to the rats on the day 10 of pregnancy. Animals were randomly divided into six groups (10-15 rats in each group); (I) normal pregnant (II) preeclamptic (III, IV, V) preeclamptic + tempol 20, 60 and 180 mg/kg/day, respectively, (VI) preeclamptic + hydralazine 10 mg/kg/day. Urine levels of sodium, potassium, creatinine, lactate dehydrogenase and 24 h protein, blood levels of creatinine and urea, in addition to malondialdehyde concentration in blood and kidney, as well as histological glomeruli changes were assessed. Results: L-NAME administration caused proteinuria and glomerular pathological changes. Tempol (20 and 60 mg/kg/day) significantly reduced plasma and renal (P< 0.001) malondialdehyde levels and proteinuria (the biggest calculated P-value was less than 0.05) in preeclamptic rats. Tempol at the dose of 20 mg/kg/day improved the histological changes in preeclamptic animals, but the dose of 60 mg/kg/day restored histological findings. L-NAME did not change the other measured parameters. Hydralazine and highest dose of tempol (180 mg/kg/day) failed to affect biochemical and histological changes in experimental preeclampsia. Conclusion: Renal complications of experimental preeclampsia such as proteinuria and glomerular injuries can be prevented by tempol. The desired effects of tempol depend on its dose.
کلیدواژه‌های انگلیسی مقاله Tempol, Rats, Preeclampsia, Oxidative Stress, Proteinuria.
نویسندگان مقاله محمد شریف طالبیان پور | mohammad sharif talebianpoor
herbal medicine research center, school of medicine, yasouj university of medical sciences, yasouj, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی یاسوج (Yasouj university of medical sciences)

سید محمد اوجی | seyed mohammad owji
department of pathology, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

محسن گوهری نیا | mohsen goharinia
department of pharmacology, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

حسین میرخانی | hossein mirkhani
department of pharmacology, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نشانی اینترنتی http://phypha.ir/ppj/browse.php?a_code=A-10-984-1&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/26/article-26-445665.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pharmacology
نوع مقاله منتشر شده Original Research
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