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Iranian Journal of Pediatric Hematology and Oncology، جلد ۵، شماره ۳، صفحات ۱۵۷-۱۶۵
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عنوان انگلیسی Effect of Sodium Bicarbonate and Sodium Chloride on Renal and Hematologic Factors in Patients with Glucose-6-phosphate Dehydrogenase Deficiency
چکیده انگلیسی مقاله Background: Sodium bicarbonate serum therapy is used for compensation bicarbonate lost and increasing blood pH in metabolic acidosis caused by severe anemia in patient with glucose-6-phosphate dehydrogenase (G6PD) deficiency. The aim of present study was comparison the effect of serum therapy using two different serums (serum with bicarbonate and without bicarbonate) on some renal and hematologic factors and their side effects in patients with hemolysis caused by G6PD deficiency. Materials and Methods: In this clinical trial study, 79 patients with favism randomly put into two treatment groups, sodium bicarbonate and sodium chloride fluid therapy. During treatment, patients received blood based on hemoglobin (Hb). Duration of hospitalization, times of Blood transfusion, received blood volume, duration of cleaning UA of Hb, Hb, urine pH and granular casts in UA were evaluated. Results: The mean age of patients was 51.22 ± 37.86 months and there were 58 males and 21 females. Only duration of hospitalization and urine pH statistically showed a significant difference between two treatment groups (P=0.036 and P> 0.01, respectively), and other factors were statistically almost identical. Conclusion: The efficiency of sodium chloride was more than sodium bicarbonate in reducing the duration of hospitalization and the small clinical difference between received blood volumes, hemoglobin changes and duration of removing hemoglobin in UA, suggest, properly, sodium chloride can be more effective on improvement of hemolysis. Lack of side effects such as metabolic acidosis, heart damage and kidney failure in children can be due to controlled injection method, the concentration of soluble drugs and small size of studied population. 
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نویسندگان مقاله نرگس بیگم میربهبهانی | narges beigom mirbehbahani
associate professor, pediatric hematology and oncology, neonatal and childrens health research center , golestan unive


آیسان salamikhanshan | aysan salamikhanshan
pediatric hematology and oncology, taleghani hospital, gorgan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

بارانک صفاییان | baranak safaian
assistant professor, pediatric nephrology, department of pediatric nephrology, golestan university of medical sciences,

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

سکینه محمدیان | sakineh mohammadian
4. associate professor, pediatrician, department of pediatric, golestan university of medical sciences, gorgan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

ناصر بهنام پور | nasser behnampour
5. assistant professor, biology statistic, department of hygiene , golestan university of medical sciences, gorgan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

صفا آرین نژاد | safa ariannejad
pediatrician, department of pediatric, taleghani hospital, gorgan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

علیرضا masoomnia | ali reza masoomnia
pediatric hematology and oncology, department of pediatric hematology and oncology, taleghani hospital, gorgan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

آذین ملک مرزبان | azin malekmarzban
hemophilia and thalassemia research center, tleghani hospital, gorgan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

اعظم رشیدباغان | azam rashidbaghan
ph.d candidate, cellular and molecular biology, medical biology research center, kermanshah university of medical scien

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-70-88&slc_lang=fa&sid=en
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