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Iranian Journal of Pediatric Hematology and Oncology، جلد ۳، شماره ۴، صفحات ۱۳۸-۱۴۲
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عنوان انگلیسی Evaluation of neuropathy during intensive vincristine chemotherapy for non-Hodgkin's lymphoma and Acute Lymphoblastic Leukemia
چکیده انگلیسی مقاله Back ground: Vincristine (VCR), is a chemotherapy drug, useful in the treatment of leukemia, lymphoma and solid tumor and it is a potent neurotoxin and sensory neuropathy drug which a common behavioral toxicity of this drug. Neuropathy is common squeal of intensive chemotherapy protocols that contain vincristine and corticosteroids. Materials and Methods: This study was a retrospective and descriptive study of neuropathy during in chemotherapy program with vincristine for patients with non-Hodgkin's lymphoma (NHL) and Acute Lymphoblastic Leukemia (ALL). Data was analyzed by spss Version16 software. Results: From total of 51 cases, 23 patients had vincristine neuropathy (45%). Patients with visceral neuropathy have shown ileus, constipation in 13 patients (25%), occasionally severe diarrhea 11 (21%), mild diarrhea 7 (13.7%) and transient diarrhea in 16 patients (31%). Motor neuropathy were found in one patient with Bell, s palsy (1.9%) and one patient with Hoarseness. 12 patients (23.5%) had some type of complication together with sensory peripheral neuropathy. Conclusion: Almost half of patients with vincristin chemotherapy had neuropathy and the mean age of patients with neuropathy was 12.3 years.
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نویسندگان مقاله m درچین | m dorchin
radiation oncologist, oncology department, dezfol university of medical sciences. dezfol. iran


r معصومی | r masoumi dehshiri
health policy research center, shahid sadoughi university of medical sciences and health services, yazd, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی دزفول (Dezful university of medical sciences)

s سلیمان | s soleiman
hematooncologist, oncology department, al-bairouni university hospital, medical faculty, damascus university, damascus,

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید صدوقی یزد (Shahid sadooghi university of medical sciences)

m manashi | m manashi
hematooncologist, oncology department, al-bairouni university hospital, medical faculty, damascus university, damascus,

سازمان اصلی تایید شده: 0 دانشگاه های خارج از کشور

نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-1-98&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/202/article-202-449177.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده 1
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