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Journal of Medical Microbiology and Infectious Diseases، جلد ۴، شماره ۳، صفحات ۷۶-۸۲
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عنوان انگلیسی Antibiotic Resistance Pattern and Phylogenetic Groups of the Uropathogenic Escherichia coli Isolates Recovered from the Urinary Catheters of the Hospitalized Patients
چکیده انگلیسی مقاله Introduction: Almost 80% of nosocomial urinary tract infections (UTIs) are due to catheterization. Catheter-associated UTI (CAUTI) is the primary source for colonization of antibiotic-resistant pathogens, and uropathogenic Escherichia coli (UPEC) is the most common causative bacteria. This study was conducted to determine the phylogenetic groups, and antibiotic resistance pattern as the two important features of pathogenicity of UPEC isolates collected from urinary catheters. Methods: The UPEC isolates were obtained from the urinary catheters of the patients without UTI, from two referral hospitals during 2015 to 2016. Phylogenetic grouping was performed using a multiplex PCR. Antibiotic susceptibility and extended spectrum beta-lactamase (ESBL) production were tested by the disc diffusion method. Multidrug resistance was determined based on a recent guideline. The presence of some resistance genes was examined by a PCR assay. Results: Thirty-eight percent of the isolates were UPEC, all of them belonged either to B2 (62.5%) or D (37.5%) phylogenetic groups. The UPEC isolates showed a very high resistance to ciprofloxacin (80%) and the third-generation cephalosporins (72.5%). Seventy percent of the isolates were ESBL-producing, and 90% of them were multiple drug resistant (MDR). Meanwhile, the frequency of the resistance genes: ctxM, aacIV, sul1, shv, and qnrA in the isolates were 95%, 82.5%, 77.5%, 72.5%, and 45%, respectively. Conclusion: High resistance to fluoroquinolones and third-generation cephalosporins, as well as high frequency of ESBL-producing and MDR UPEC isolates, are a great concern. This phenomenon is probably the consequence of the indiscriminate use and on the counter availability of antibiotics, which should be considered in empirical therapy of CAUTIs.
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نویسندگان مقاله مرضیه طاهری | marziye taheri
department of molecular biology, pasteur institute of iran, no. 69, pasteur ave., tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

معین صالح | moein saleh
department of molecular biology, pasteur institute of iran, no. 69, pasteur ave., tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

امیر حسام نعمتی | amir hesam nemati
department of bacteriology, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

مهدی آریانا | mehdi ariana
department of microbial biotechnology, school of biology, college of science, university of tehran, tehran, iran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

اسفندیار شجاعی | esfandiar shojaei
infectious diseases ward, imam khomeini hospital complex, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مسعود مردانی | masoud mardani
infectious diseases ward, loghman hakim hospital, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

محمد کتولی | mohammad katouli
genecology research centre, faculty of science, health, education and engineering, university of the sunshine coast, maroochydore, queensland, australia


محمد پویا | mohammad pooya
department of molecular biology, pasteur institute of iran, no. 69, pasteur ave., tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

نشانی اینترنتی http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-71-1&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/350/article-350-449764.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Anti-microbial agents, resistance and treatment protocols
نوع مقاله منتشر شده Original article
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