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Iranian Journal of Basic Medical Sciences، جلد ۱۹، شماره ۱۱، صفحات ۱۱۷۱-۱۱۷۶
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عنوان انگلیسی The hedgehog/Gli-1 signaling pathways is involved in the inhibitory effect of resveratrol on human colorectal cancer HCT116 cells
چکیده انگلیسی مقاله Objective(s): The study aimed to investigate the effects of resveratrol on colorectal cancer HCT116 cells, including cell viability, apoptosis, and migration, and the partial mechanisms focused on hedgehog/gli-1 signaling pathways. Materials and Methods: We chose the appropriate time and concentration of recombinant human Sonic hedgehog (Shh) stimulation by cell viability. The proportion of cell apoptosis was detected by flow cytometry; HCT116 cell migration was measured by scratch test; the expression of Ptch, Smo, and Gli-1 was measured by Western blot analysis. Results: Shh signaling increased HCT116 cell viability and migration, inhibited cell apoptosis, and upregulated the expression of Ptch, Smo, and Gli-1. Resveratrol obviously inhibited HCT116 cell viability and migration, promoted cell apoptosis, and suppressed the protein of Ptch, Smo, and Gli-1. Furthermore, the effects of resveratrol and Shh on human colorectal cancer HCT116 cells were in a dose- and time-dependent manner. Conclusion: The inhibitory effect of resveratrol on HCT116 cells may be mediated by hedgehog/gli-1 signaling pathways.
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نویسندگان مقاله zhou du | zhou du
department of gastrointestinal surgery, the first affiliated hospital of wenzhou medical university, wenzhou 325035, zhejiang province, china


feng zhou | feng zhou
department of gastrointestinal surgery, the first affiliated hospital of wenzhou medical university, wenzhou 325035, zhejiang province, china


zengrong جیا | zengrong jia
department of gastrointestinal surgery, the first affiliated hospital of wenzhou medical university, wenzhou 325035, zhejiang province, china


beishi zheng | beishi zheng
department of gastrointestinal surgery, the first affiliated hospital of wenzhou medical university, wenzhou 325035, zhejiang province, china


shaoliang هانیه | shaoliang han
department of gastrointestinal surgery, the first affiliated hospital of wenzhou medical university, wenzhou 325035, zhejiang province, china


جون چنگ | jun cheng
department of gastrointestinal surgery, the first affiliated hospital of wenzhou medical university, wenzhou 325035, zhejiang province, china


guanbao zhu | guanbao zhu
department of gastrointestinal surgery, the first affiliated hospital of wenzhou medical university, wenzhou 325035, zhejiang province, china


ping هوانگ | ping huang
office of development and planning, wenzhou medical university, wenzhou 325035, zhejiang province, china
نشانی اینترنتی http://ijbms.mums.ac.ir/article_7816.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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