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Iranian Journal of Basic Medical Sciences، جلد ۱۹، شماره ۱۰، صفحات ۱۰۴۹-۱۰۵۵
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عنوان انگلیسی Pharmacokinetic study of furosemide incorporated PLGA microspheres after oral administration to rat
چکیده انگلیسی مقاله Objective(s): The purpose of the current study was to assess the feasibility of microspheres from biocompatible polymer for oral bioavailability (BA) enhancement of potent sulfonamide- type loop diuretic- Furosemide - which used in the treatment of congestive heart failure, caused edema, cirrhosis, renal disease and as an adjunct in acute pulmonary edema. The comparatively poor and inconstant BA of furosemide, which occurs site-specifically in the stomach and upper small intestine, has been ascribed to the poor dissolution of furosemide. Materials and Methods: In attempt to enhance the drug BA, poly (dl-lactic-co-glycolic acid) (PLGA) microspheres of furosemide were obtained using solvent-evaporation method and the carrier characteristics were investigated subsequently. Results: The in vivo performance of optimum formulation was assessed by pharmacokinetic evaluation of drug after orally administration of free and loaded in microspheres to rats (4 mg/Kg). For this reason, the concentration of drug in plasma was measured by a new developed and sensitive method of HPLC. Acceptable drug loading and encapsulation efficiency of microspheres were obtained to be 70.43 and 85.21 %, respectively. Microspheres provided improved pharmacokinetic parameters (Cmax = 147.94 ng/ml, Tmax = 1.92 hr) in rats as compared with pure drug (Cmax = 75.69 ng/ml, Tmax = 1.5 hr). The obtained AUC of drug in microsphere was 10 fold higher than of the free drug. Conclusion: The results showed that the prepared microspheres successfully improved BA of the poorly water-soluble drug effectively.
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نویسندگان مقاله کتایون درخشنده | katayoun derakhshandeh
nano drug delivery research center, kermanshah university of medical sciences, kermanshah, iran|department of pharmaceutics, school of pharmacy, hamadan university of medical sciences, hamadan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

معین کریمی | moin karimi
department of pharmaceutics, school of pharmacy, hamadan university of medical sciences, hamadan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

عباس همتی ازندریانی | abbas hemati azandaryani
department of pharmaceutics, school of pharmacy, hamadan university of medical sciences, hamadan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

غلامرضا بهرامی | gholamreza bahrami
department of pharmacology and toxicology, school of pharmacy, kermanshah university of medical sciences, kermanshah

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

kiumras قنبری | kiumras ghanbari
department of pharmacology and toxicology, school of pharmacy, kermanshah university of medical sciences, kermanshah

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_7729.html
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زبان مقاله منتشر شده en
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