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Iranian Journal of Basic Medical Sciences، جلد ۱۹، شماره ۹، صفحات ۱۰۱۰-۱۰۱۵
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عنوان انگلیسی Prednison provokes serum and vasoactive substances in a mice model of immune thrombocytopenia
چکیده انگلیسی مقاله Objective(s): The main objective of this study was to investigate the variations of β-endorphin (β-EP), vasoactive intestinal peptide (VIP), serotonin (5-HT) and norepinephrine (NE) of immune thrombocytopenia (ITP) mice as well as the regulatory mechanism of prednison. Materials and Methods: Sixty BALB/c mice were randomly divided into control group, model group and prednison intervention group. ITP mice model was duplicated by injecting with glycoprotein-antiplatelet serum (GP-APS) except in control group. After ITP disease model was successful established, prednison was used in prednison intervention group. The β-EP, VIP, 5-HT and NE contents of ITP mice were detected by enzyme linked immunosorbent assay (ELISA). Results:Compared with the values in control group, the detection values of VIP and 5-HT in model group declined, while the detection values of β-EP and NE increased. Compared with prednison intervention group, the detection values of VIP and 5-HT in model group increased, while the detection values of β-EP and NE showed no significant change. Conclusion: In this study, the β-EP, VIP, 5-HT and NE contents in ITP mice injected with GP-APS were changed by prednison. It shows that prednison as the first-line therapy for ITP with effective hemostasis function is likely to increasing the contents of VIP and 5-HT. These results suggest the therapeutic value of prednison for the treatment of ITP.
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نویسندگان مقاله ling زانگ | ling zhang
dongzhimen hosp. beijing university of chinese medicine. no. 5 haiyuncang, dongcheng district, beijing, china


ke chen | ke chen
dongzhimen hosp. beijing university of chinese medicine. no. 5 haiyuncang, dongcheng district, beijing, china


tiantian li | tiantian li
dongzhimen hosp. beijing university of chinese medicine. no. 5 haiyuncang, dongcheng district, beijing, china


hao he | hao he
school of pharmacy, xi’an medical college, shanxi 710021, china


li hou | li hou
dongzhimen hosp. beijing university of chinese medicine. no. 5 haiyuncang, dongcheng district, beijing, china


xiaoyong wu | xiaoyong wu
no. 1 hospital affiliated to guiyang college of tcm, guiyang 550001, china


yanping سون | yanping sun
school of pharmacy, xi’an medical college, shanxi 710021, china


lei zheng | lei zheng
school of pharmacy, xi’an medical college, shanxi 710021, china


zhixiong chen | zhixiong chen
no. 1 hospital affiliated to guangzhou university of chinese medicine, guangzhou 510405, china


bei qin | bei qin
school of pharmacy, xi’an medical college, shanxi 710021, china


xinyi chen | xinyi chen
dongzhimen hosp. beijing university of chinese medicine. no. 5 haiyuncang, dongcheng district, beijing, china


shaodan tian | shaodan tian
dongzhimen hosp. beijing university of chinese medicine. no. 5 haiyuncang, dongcheng district, beijing, china
نشانی اینترنتی http://ijbms.mums.ac.ir/article_7602.html
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زبان مقاله منتشر شده en
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