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Iranian Journal of Basic Medical Sciences، جلد ۱۹، شماره ۹، صفحات ۱۰۱۶-۱۰۲۳
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عنوان انگلیسی Total flavonoid extract from Coreopsis tinctoria Nutt. protects rats against myocardial ischemia/reperfusion injury
چکیده انگلیسی مقاله Objective(s): This study aimed to evaluate the protective effects of total flavonoid extract from Coreopsis tinctoria Nutt.(CTF)against myocardial ischemia/reperfusion injury (MIRI) using an isolated Langendorff rat heart model. Materials and Methods: Left ventricular developed pressure (LVDP) and the maximum rate of rise and fall of LV pressure (±dp/dtmax) were recorded. Cardiac injury was assessed by analyzing lactate dehydrogenase (LDH) and creatine kinase (CK) released in the coronary effluent. Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) levels were determined. Myocardial inflammation was assessed by monitoring tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), interleukin-8 (IL-8), and interleukin-6 (IL-6) levels. Myocardial infarct size was estimated. Cell morphology was assessed by 2,3,5-triphenyltetrazolium chloride and hematoxylin and eosin (HE) staining. Cardiomyocyte apoptosis was determined by terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) staining. Results: Pretreatment with CTF significantly increased the heart rate and increased LVDP, as well as SOD and GSH-Px levels. In addition, CTF pretreatment decreased the TUNEL-positive cell ratio, infarct size, and levels of CK, LDH, MDA, TNF-α, CRP, IL-6, and IL-8. Conclusion: These results suggest that CTF exerts cardio-protective effects against MIRI via anti-oxidant, anti-inflammatory, and anti-apoptotic activities.
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نویسندگان مقاله ya زانگ | ya zhang
ministry of education, pharmacy shihezi university xinjiang china


changsheng yuan | changsheng yuan
ministry of education, pharmacy shihezi university xinjiang china


he fang | he fang
ministry of education, pharmacy shihezi university xinjiang china


جیا li | jia li
ministry of education, pharmacy shihezi university xinjiang china


shanshan su | shanshan su
ministry of education, pharmacy shihezi university xinjiang china


wen chen | wen chen
pharmacy shihezi university xinjiang china
نشانی اینترنتی http://ijbms.mums.ac.ir/article_7603.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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