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Iranian Journal of Basic Medical Sciences، جلد ۱۹، شماره ۸، صفحات ۸۶۳-۸۶۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The effects of unilateral varicose ovarian vein on antioxidant capacity and oocyte quality in rat ovary
چکیده انگلیسی مقاله Objective(s): Several researchers have reported the relationship between infertility in male and varicocele for so many years but the implication of varicocele in female patients is remains elusive. Here, we aim to examine the effects of unilateral varicose ovarian vein on antioxidant capacity and oocyte quality of rat ovary after the experimental creation of varicocele in female rats. Materials and Methods: In this study, thirty adult female albino rats were divided into three equal groups: Group 1 as the control group has 10 rats, Group 2 as the sham group has 10 rats and they underwent a sham operation and finally Group 3 has the varicocele group has 10 rats. Antioxidant assays for superoxide dismutase, glutathioneperoxidase and catalase were performed using specific assay kits and gene expression for Bax, Bmp-15, Hsp-27 and Gdf-9 was done via real time PCR. Results: The adverse effects of the experimentally induced varicocele were reported and recorded on the left ovary compared to the right sided ovary (no varicocele induction) in the varicocele group. Real time PCR data shows that the expression of Gdf-9, Hsp-27 and Bmp-15 genes were all significantly reduced at P≤0.05. Conclusion: The results of this study show that reduced gene expression of Bmp-15, Gdf-9 and Hsp-27, increased gene expression of bax and an imbalance between pro-oxidant/ antioxidant ratio are few of the several mechanisms by which varicocele may lead to infertility in female.
کلیدواژه‌های انگلیسی مقاله Antioxidant, Oocyte, Ovary, Varicose veins
نویسندگان مقاله babatunde adebayo kehinde | babatunde adebayo kehinde
school of medicine, international campus, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فرید ابوالحسنی | farid abolhassani
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

حسین یزدخواستی | hossein yazdekhasti
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نیلوفر عباسی | niloufar abbasi
emergency sections, vali-asr hospital, shahrekord university of medical sciences, borujen, iran


لیلا حیدری | leyla heydari
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

عرفان دانشی | erfan daneshi
department of anatomy, school of medicine, kurdistan university of medical sciences, sanandaj, iran


زهرا رجبی | zahra rajabi
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سید علا hamada | alaa hamada
department of urology, st elizabeth medical center, tufts university, brighton, ma, usa


ashok agarwal | ashok agarwal
american center for reproductive medicine, cleveland clinic foundation, cleveland, oh, usa


مهدی عباسی | mehdi abbasi
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_7468.html
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