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Iranian Journal of Basic Medical Sciences، جلد ۱۹، شماره ۸، صفحات ۹۱۰-۹۱۵
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عنوان انگلیسی Hepatoprotective effects of licochalcone B on carbon tetrachloride-induced liver toxicity in mice
چکیده انگلیسی مقاله Objective(s): The objective of this study was to investigate the hepatoprotective effect of licochalcone B (LCB) in a mice model of carbon tetrachloride (CCl4)-induced liver toxicity. Materials and Methods: Hepatotoxicity was induced in mice by a single subcutaneous injection (SC) of CCl4. The LCB was administered orally once a day for seven days (PO) as pretreatment at three doses of 1, 5, and 25 mg/kg/day. The levels of superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), glutathione disulfide (GSSG), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were analyzed by ELISA. The protein expression degrees of p38 mitogen activated protein kinases (p38) and nuclear factor-k-gene binding (NF-κB) were assayed by western blotting. Results: CCl4-induced hepatotoxicity was manifested by an increase in the levels of ALT, AST, MDA, IL-6, CRP, and TNF-ɑ, and a decrease in the SOD level and GSH/GSSG ratio in the serum. The histopathological examination of the liver sections revealed necrosis and inflammatory reactions. Pretreatment with LCB decreased the levels of ALT, AST, MDA, GSSG, IL-6, CRP, TNF-ɑ, and the protein expression of p38 and NF-κB, increased the level of SOD and GSH, and normalized the hepatic histo-architecture. Conclusion: LCB protected the liver from CCl4-induced injury. Protection may be due to inhibition of p38 and NFκB signaling, which subsequently reduced inflammation in the liver.
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نویسندگان مقاله haifeng teng | haifeng teng
weihai municipal hospital, china


meng chen | meng chen
yantai yuhuangding hospital of laishan branch, china


ansheng chu | ansheng chu
yantai city hospital for infectious diseases, china


haili jiang | haili jiang
shuguang hospital, shanghai university of traditional chinese medicine, china


jichun هانیه | jichun han
shandong provincial qianfoshan hospital, china


لنگ سون | long sun
yishui central hospital, china


chao feng | chao feng
yantaishan hospital, china


ju liu | ju liu
shandong provincial qianfoshan hospital, china
نشانی اینترنتی http://ijbms.mums.ac.ir/article_7474.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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