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Iranian Journal of Basic Medical Sciences، جلد ۱۹، شماره ۶، صفحات ۵۹۴-۶۰۰
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عنوان انگلیسی Swimming exercise attenuates psychological dependence and voluntary methamphetamine consumption in methamphet- amine withdrawn rats
چکیده انگلیسی مقاله Objective(s): This study evaluated the effect of swimming exercise during spontaneous methamphetamine (METH) withdrawal on the anxiety, depression, obsessive-compulsive disorder (OCD) and voluntary METH consumption in METH-dependent rats. Materials and Methods: Male Wistar rats were repeatedly administered with bi-daily doses of METH (2 mg/kg, subcutaneous) over a period of 14 days. Exercised rats were submitted to swimming sessions (45 min/day, five days per week, for 14 days) during spontaneous METH-withdrawal. Then, all animals were tested for the assessment of anxiety by using the elevated plus-maze (EPM), the grooming behaviors (OCD), and depression using forced swimming test (FST) and voluntary METH consumption using a two-bottle choice (TBC) paradigm for the assessment of craving. Results: The results showed that the swimmer METH-withdrawn rats exhibited an increase in EPM open arm time and entries and a reduction of immobility and grooming behaviors compared with the sedentary METH groups. Also, voluntary METH consumption was less in the swimmer METH-withdrawn rats than the sedentary METH groups throughout 5–8 days. Conclusion: This study showed that regular swimming exercise reduced voluntary METH consumption in animal models of craving by reducing anxiety, OCD, and depression in the METH-withdrawn rats. Thus, physical training may be ameliorating some of the withdrawal behavioral consequences of METH.
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نویسندگان مقاله فاطمه دامغانی | fatemeh damghani
faculty of psychology and educational sciences, university of semnan, semnan, iran

سازمان اصلی تایید شده: دانشگاه سمنان (Semnan university)

ایمان الله بیگدلی | imanollah bigdeli
faculty of educational sciences and psychology, ferdowsi university of mashhad, mashhad, iran

سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)

حسین میلادی گرجی | hossein miladi gorji
laboratory of animal addiction models, research center and department of physiology, school of medicine, semnan university of medical sciences, semnan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)

عاطفه فدایی | atefeh fadaei
faculty of psychology and educational sciences, university of semnan, semnan, iran

سازمان اصلی تایید شده: دانشگاه سمنان (Semnan university)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_7126.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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