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Iranian Journal of Basic Medical Sciences، جلد ۱۹، شماره ۶، صفحات ۶۲۴-۶۳۱
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عنوان انگلیسی Effect of ischemic preconditioning on the expression of c-myb in the CA1 region of the gerbil hippocampus after ischemia/reperfusion injury
چکیده انگلیسی مقاله Objective(s): In the present study, we investigated the effect of ischemic preconditioning (IPC) on c-myb immunoreactivity as well as neuronal damage/death after a subsequent lethal transient ischemia in gerbils. Materials and Methods: IPC was subjected to a 2 min sublethal ischemia and a lethal transient ischemia was given 5 min transient ischemia. The animals in all of the groups were given recovery times of 1 day, 2 days and 5 days and we examined change in c-myb immunoreactivity as well as neuronal damage/death in the hippocampus induced by a lethal transient ischemia. Results:A lethal transient ischemia induced a significant loss of cells in the stratum pyramidale (SP) of the hippocampal CA1 region at 5 days post-ischemia, and this insult showed that c-myb immunoreactivity in cells of the SP of the CA1 region was significantly decreased at 2 days post-ischemia and disappeared at 5 days post-ischemia. However, IPC effectively prevented the neuronal loss in the SP and showed that c-myb immunoreactivity was constitutively maintained in the SP after a lethal transient ischemia. Conclusion: Our results show that a lethal transient ischemia significantly decreased c-myb immunoreactivity in the SP of the CA1 region and that IPC well preserved c-myb immunoreactivity in the SP of the CA1 region. We suggest that the maintenance of c-myb might be related with IPC-mediated neuroprotection after a lethal ischemic insult.
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نویسندگان مقاله هیو یانگ lee | hui young lee
department of internal medicine, school of medicine, kangwon national university, chuncheon 200-701, south korea


hyun جین tae | hyun jin tae
department of biomedical science, research institute of bioscience and biotechnology, hallym university, chuncheon 200-702, south korea


geum sil cho | geum sil cho
pharmacology amp;amp; toxicology department, shinpoong pharmaceutical co., ltd., ansan 425-100, south korea


in hye کیم | in hye kim
department of neurobiology, school of medicine, kangwon national university, chuncheon 200-701, south korea


jeong hwi cho | jeong hwi cho
department of neurobiology, school of medicine, kangwon national university, chuncheon 200-701, south korea


جون ha سونگ گو | joon ha park
department of neurobiology, school of medicine, kangwon national university, chuncheon 200-701, south korea


ji hyeon ahn | ji hyeon ahn
department of biomedical science, research institute of bioscience and biotechnology, hallym university, chuncheon 200-702, south korea


بای هیو chen | bai hui chen
department of physiology, college of medicine, hallym university, chuncheon 200-702, south korea


bich na shin | bich na shin
department of physiology, college of medicine, hallym university, chuncheon 200-702, south korea


محمدناصر ho won | moo ho won
department of neurobiology, school of medicine, kangwon national university, chuncheon 200-701, south korea


چان woo سونگ گو | chan woo park
department of emergency medicine, school of medicine, kangwon national university, chuncheon 200-701, south korea


جون hwi cho | jun hwi cho
department of emergency medicine, school of medicine, kangwon national university, chuncheon 200-701, south korea


jeong yeol seo | jeong yeol seo
department of emergency medicine, chuncheon sacred heart hospital, college of medicine, hallym university, chuncheon 200-702, south korea


jae chul lee | jae chul lee
department of neurobiology, school of medicine, kangwon national university, chuncheon 200-701, south korea
نشانی اینترنتی http://ijbms.mums.ac.ir/article_7130.html
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نوع مقاله منتشر شده Original Article
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