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Iranian Journal of Basic Medical Sciences، جلد ۱۹، شماره ۶، صفحات ۶۸۵-۶۹۱
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چکیده فارسی مقاله
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عنوان انگلیسی The protective effect of infliximab against carbon tetrachloride-induced acute lung injury
چکیده انگلیسی مقاله Objective(s): Carbon tetrachloride (CCl4) causes pulmonary toxicity. Infliximab (Ib) is a potent inhibitor of tumor necrosis factor-alpha (TNF-α). We aimed to investigate whether Ib has a protective effect on CCl4 induced lung injury. Materials and Methods:Rats were divided into control, CCl4, and CCl4+Ib groups. A single dose of 2 ml/kg CCI4 was administered to CCI4 group and a single dose of 7 mg/kg Ib was given to CCl4+Ib group 24 hr before applying CCI4. Results:TNF-α, malondialdehyde (MDA), nitric oxide (NO) and caspase-3 levels of the CCl4 group were markedly higher than both the control and CCl4+Ib groups. The CCI4+Ib group had lower histopathological injury than the CCl4 group. Conclusion:Ib as a strong TNF-α blocker decreases the production of proinflammatory cytokines, MDA, and oxidative stress leading to a protective effect against CCl4 induced lung tissue injury.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله aysel kurt | aysel kurt
recep tayyip erdogan university, school of medicine, department of thoracic surgery, rize, turkey


levent tumkaya | levent tumkaya
recep tayyip erdogan university, school of medicine, department of histology and embryology, rize, turkey


suleyman yuce | suleyman yuce
department of internal medicine, ordu kumru state hospital, ordu, turkey


حسن turut | hasan turut
recep tayyip erdogan university, school of medicine, department of thoracic surgery, rize, turkey


medine cumhur cure | medine cumhur cure
recep tayyip erdogan university, school of medicine, department of biochemistry, rize, turkey


ابراهیم sehitoglu | ibrahim sehitoglu
recep tayyip erdogan university, school of medicine, department of pathology, rize, turkey


yildiray kalkan | yildiray kalkan
recep tayyip erdogan university, school of medicine, department of histology and embryology, rize, turkey


gokhan pusuroglu | gokhan pusuroglu
recep tayyip erdogan university, school of medicine, department of internal medicine, rize, turkey


erkan cure | erkan cure
recep tayyip erdogan university, school of medicine, department of internal medicine, rize, turkey
نشانی اینترنتی http://ijbms.mums.ac.ir/article_7138.html
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Short Communications
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