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Iranian Journal of Basic Medical Sciences، جلد ۱۹، شماره ۵، صفحات ۴۹۰-۴۹۶
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عنوان انگلیسی Effect of WR-1065 on 6-hydroxydopamine-induced catalepsy and IL-6 level in rats
چکیده انگلیسی مقاله Objective(s): Neuroinflammation and oxidative stress play a key role in pathogenesis of Parkinson’s disease (PD). In the present study we investigated the effect of reactive oxygen species (ROS) scavenger WR-1065 on catalepsy and cerebrospinal fluid (CSF) level of interleukin 6(IL-6) and striatum superoxide dismutase (SOD) activity in 6-hydroxydopamine (6-OHDA) induced experimental model of PD. Materials and Methods: Seventy two male Wistar rats were divided into 9 equal groups and 6-OHDA (8 μg/2 μl/rat) was infused unilaterally into substantia nigra pars copmacta (SNc) to induce PD. Catalepsy was measured by standard bar test, CSF level of IL-6 was assessed by enzyme-linked immunosorbent assay (ELISA) method and SOD activity measured by spectrophotometric method. In pre-treatment groups WR-1065 (20, 40 and 80 μg/2 μl/rat/day, for 3 days) was infused into the SNc before 6-OHDA administration and 21 days later, as a recovery period, behavioral and molecular assay tests were done. Results: Our results showed that pre-treatment with WR-1065 improved (P< 0.001) 6-OHDA-induced catalepsy in a dose dependent manner. In 6-OHDA-lesioned animals SOD activity in SNc and CSF level of IL-6 was decreased markedly (P< 0.001) when compared with non-lesioned group, while pre-treatment with WR-1065(P< 0.001) restored their levels up to the normal range. Conclusion: Our study indicated that pre-treatment with WR-1065 could modulate catalepsy and IL-6 level in 6-OHDA-lesioned rats. Also WR1065 could increase SOD activity up to normal range. It can be regarded as an anti-oxidative drug in prevention or adjunctive therapy of PD.
کلیدواژه‌های انگلیسی مقاله Catalepsy, IL-6, Rat, SOD, WR-1065
نویسندگان مقاله افشین خردمند | afshin kheradmand
drug applied research center, department of pharmacology and toxicology, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

علیرضا محجل نایبی | alireza mohajjel nayebi
drug applied research center, department of pharmacology and toxicology, tabriz university of medical sciences, tabriz, iran|department of pharmacology and toxicology, faculty of pharmacy, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

معصومه جرجانی | masoumeh jorjani
department of pharmacology and neurobiology research center, faculty of medicine, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

رسول حدادی | rasool haddadi
department of pharmacology and toxicology, faculty of pharmacy, hamadan university of medical sciences, hamadan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_6933.html
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