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Iranian Journal of Basic Medical Sciences، جلد ۱۹، شماره ۵، صفحات ۵۶۷-۵۷۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Enhanced expression of transient receptor potential channel 3 in uterine smooth muscle tissues of lipopolysaccharide-induced preterm delivery mice
چکیده انگلیسی مقاله Objective(s): We aimed to investigate the influence of transient receptor potential channel 3 (TRPC3) on lipopolysaccharide-induced (LPS) preterm delivery mice. Materials and Methods: Mice were randomly assigned to the four groups: an unpregnant group, a mid-pregnancy group (E15), a term delivery group, and an LPS-induced preterm delivery group (intraperitoneal injection LPS at 15 days). Uterine smooth muscles were obtained through caesarean section; TRPC3 expression was measured by real-time PCR, western blotting, and immunohistochemistry. A specific inhibitor of TRPC3 (SKF96365) was injected into the LPS-induced preterm delivery group to determine whether the delivery interval was prolonged. Results: TRPC3 was primarily expressed in the uterine smooth muscle layer. In addition, the LPS-induced preterm delivery group had an obviously higher expression level of TRPC3 mRNA and protein compared with the unpregnant and E15 groups, which were close to term delivery. More importantly, SKF96365 prolongs the delivery interval of LPS-induced preterm delivery mice. Conclusion: Enhanced expression of TRPC3 may be associated with LPS-induced preterm delivery in mice. The specific inhibitor of TRPC3 (SKF96365) may be helpful for clinical treatment of preterm delivery.
کلیدواژه‌های انگلیسی مقاله Preterm delivery, SKF96365, TRPC3, Uterine muscle
نویسندگان مقاله dongming zheng | dongming zheng
department of obstetrics and gynecology, shengjing hospital of china medical university, shenyang, china


lijuan زانگ | lijuan zhang
department of obstetrics and gynecology, shengjing hospital of china medical university, shenyang, china


quan na | quan na
department of obstetrics and gynecology, shengjing hospital of china medical university, shenyang, china


sishi liu | sishi liu
department of obstetrics and gynecology, shengjing hospital of china medical university, shenyang, china


yanyan zhuang | yanyan zhuang
department of obstetrics and gynecology, shengjing hospital of china medical university, shenyang, china


yuan lv | yuan lv
department of obstetrics and gynecology, shengjing hospital of china medical university, shenyang, china


caixia liu | caixia liu
department of obstetrics and gynecology, shengjing hospital of china medical university, shenyang, china
نشانی اینترنتی http://ijbms.mums.ac.ir/article_6942.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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