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Iranian Journal of Basic Medical Sciences، جلد ۱۹، شماره ۲، صفحات ۱۶۶-۱۷۱
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عنوان انگلیسی Effect of coating thickness of iron oxide nanoparticles on their relaxivity in the MRI
چکیده انگلیسی مقاله Objective(s):Iron oxide nanoparticles have found prevalent applications in various fields including drug delivery, cell separation and as contrast agents. Super paramagnetic iron oxide (SPIO) nanoparticles allow researchers and clinicians to enhance the tissue contrast of an area of interest by increasing the relaxation rate of water. In this study, we evaluate the dependency of hydrodynamic size of iron oxide nanoparticles coated with Polyethylene glycol (PEG) on their relativities with 3 Tesla clinical MRI. Materials and Methods: We used three groups of nanoparticles with nominal sizes 20, 50 and 100 nm with a core size of 8.86 nm, 8.69 nm and 10.4 nm that they were covered with PEG 300 and 600 Da. A clinical magnetic resonance scanner determines the T1 and T2 relaxation times for various concentrations of PEG-coated nanoparticles. Results: The size measurement by photon correlation spectroscopy showed the hydrodynamic sizes of MNPs with nominal 20, 50 and 100 nm with 70, 82 and 116 nm for particles with PEG 600 coating and 74, 93 and 100 nm for particles with PEG 300 coating, respectively. We foud that the relaxivity decreased with increasing overall particle size (via coating thickness). Magnetic resonance imaging showed that by increasing the size of the nanoparticles, r2/r1 increases linearly. Conclusion: According to the data obtained from this study it can be concluded that increments in coating thickness have more influence on relaxivities compared to the changes in core size of magnetic nanoparticles.
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نویسندگان مقاله فرزانه hajesmaeelzadeh | farzaneh hajesmaeelzadeh
biomolecular imaging analysis group, research center for molecular and cellular imaging, tehran university of medical sciences, tehran, iran|department of medical physics and biomedical engineering, faculty of medicine, tehran university of medical science, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سعید شانه ساززاده | saeed shanehsazzadeh
radiation application research school, nuclear science and technology research institute, tehran, iran


cordula grüttner | cordula grüttner
micromod partikeltechnologie gmbh, friedrich-barnewitz-str. 4, d-18119 rostock, germany


فریبا جوهری دها | fariba johari daha
radiation application research school, nuclear science and technology research institute, tehran, iran


محمد علی عقابیان | mohammad ali oghabian
biomolecular imaging analysis group, research center for molecular and cellular imaging, tehran university of medical sciences, tehran, iran|department of medical physics and biomedical engineering, faculty of medicine, tehran university of medical science, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_6540.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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