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Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۱۲، صفحات ۱۲۴۵-۱۲۵۲
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عنوان انگلیسی Improvement effect of Lycium barbarum polysaccharide on sub-health mice
چکیده انگلیسی مقاله Objective(s):Sub-health has been described as a chronic condition of unexplained deteriorated physiological function, which falls between health and illness. In the present study, we evaluated the effects of Lycium barbarum polysaccharide (LBP), a polysaccharide fraction purified from Lycium barbarum (L. barbarum) on the sub-health mice. Materials and Methods:The sub-health model mice were built through compound factors. The mice were given intragastric administration of LBP at low dose (50 mg•kg-1) and high dose (100 mg•kg-1), respectively. After LBP treatment for 4 weeks, the antioxidant ability, enhancing immune function and anti-fatigue activity were detected. Results:The results showed that LBP could enhance antioxidant ability in sub-health mice. LBP could effectively improve immunity of sub-health mice and protect the immune organs, such as thymus. In addition, LBP showed anti-fatigue ability in sub-health mice. Conclusion:LBP could improve sub-health state caused from composite factor through three aspects, such as increasing antioxidant ability, promoting T lymphocyte proliferation, inhibiting thymus lymphocyte apoptosis, and alleviating fatigue.
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نویسندگان مقاله روی zhao | rui zhao
department of pharmaceutical engineering, college of life science amp;amp; biotechnology, heilongjiang august first land reclamation university, daqing high-tech industrial development zone, 163319, p.r. china


wenli hao | wenli hao
department of pharmaceutical engineering, college of life science amp;amp; biotechnology, heilongjiang bayi agricultural university, daqing high-tech industrial development zone, 163319, p.r. china


baoling ma | baoling ma
department of physical education, hebei normal university of science and technology, 360 hebei street, qinhuangdao 066004, p.r. china


zhibao chen | zhibao chen
department of pharmaceutical engineering, college of life science amp;amp; biotechnology, heilongjiang bayi agricultural university, daqing high-tech industrial development zone, 163319, p.r. china
نشانی اینترنتی http://ijbms.mums.ac.ir/article_6281.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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