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Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۱۲، صفحات ۱۲۵۳-۱۲۵۶
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عنوان انگلیسی Cholesterol suppresses antimicrobial effect of statins
چکیده انگلیسی مقاله Objective(s):Isoprenoid biosynthesis is a key metabolic pathway to produce a wide variety of biomolecules such as cholesterol and carotenoids, which target cell membranes. On the other hand, it has been reported that statins known as inhibitors of isoprenoid biosynthesis and cholesterol lowering agents, may have a direct antimicrobial effect on the some bacteria. The exact action of statins in microbial metabolism is not clearly understood. It is possible that statins inhibit synthesis or utilization of some sterol precursor necessary for bacterial membrane integrity. Accordingly, this study was designed in order to examine if statins inhibit the production of a compound, which can be used in the membrane, and whether cholesterol would replace it and rescue bacteria from toxic effects of statins. Materials and Methods: To examine the possibility we assessed antibacterial effect of statins with different classes; lovastatin, simvastatin, and atorvastatin, alone and in combination with cholesterol on two Gram-positive (Staphylococcus aureus and Enterococcus faecalis) and two Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria using gel diffusion assay. Results: Our results showed that all of the statins except for lovastatin had significant antibacterial property in S. aureus, E. coli, and Enter. faecalis. Surprisingly, cholesterol nullified the antimicrobial action of effective statins in statin-sensitive bacteria. Conclusion: It is concluded that statins may deprive bacteria from a metabolite responsible for membrane stability, which is effectively substituted by cholesterol.
کلیدواژه‌های انگلیسی مقاله Bacteria, Hydroxymethylglutaryl coenzyme A, Statin, Sterol
نویسندگان مقاله محمدرضا حایری | mohammad reza haeri
department of clinical biochemistry, school of medicine, qom university of medical sciences, qom, iran|institute for health research and policy, london metropolitan university, london, united kingdom

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قم (Qom university of medical sciences)

kenneth وایت | kenneth white
institute for health research and policy, london metropolitan university, london, united kingdom


محمد qharebeglou | mohammad qharebeglou
islamic azad university, qom branch, qom-iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

ملک معین انصار | malek moein ansar
department of clinical biochemistry, school of medicine, guilan university of medical sciences, rasht, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_6282.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Short Communications
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