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Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۱۱، صفحات ۱۰۶۳-۱۰۷۱
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عنوان انگلیسی Resveratrol protects against diet-induced atherosclerosis by reducing low-density lipoprotein cholesterol and inhibiting inflammation in apolipoprotein E-deficient mice
چکیده انگلیسی مقاله Objective(s):Resveratrol (RES) is a polyphenol compound that has been shown a promising cardioprotective effect. However, some reports have yielded conflicting findings. Herein, we investigated the anti-atherosclerotic effects of RES in apolipoprotein E (apo E)-deficient mice on a high cholesterol diet. Materials and Methods: Firstly, atherosclerosis was induced by feeding a high cholesterol diet to apo E-deficient mice. Then, we examined its effects on weight control, and serum interleukin-6 (IL-6) levels and used histopathological methods to analyze morphology and inflammatory marker of atherosclerotic lesions in mice orally supplemented with high (25 mg/kg/day) and low (5 mg/kg/day) doses of RES for 8 weeks. Results: Mice with high dose of RES had reduced epididymal fat pads, and lower serum IL-6 levels compared with those of control mice. Moreover, RES in high doses also decreased the low-density lipoprotein cholesterol (LDL-C) levels and atherogenic index (LDL-C/HDL-C) in the mice. Dissection of high-dose RES-treated mice revealed a marked reduction in fat deposition, percentage of mice with atherosclerotic lesion, and intima/media ratio in the aortic areas.Theexpressions of macrophage-specific marker F4/80 and cardiovascular inflammatory marker NF-κB in atherosclerotic vessels were both diminished in the atherosclerotic vessels of high-dose RES-supplementated apo E-deficient mice. Conclusion: These results suggest that RES prevented the effects of a high cholesterol diet onthe rate of accretion in atherosclerosis progression by reducing the LDL-C levels and suppressing atherosclerotic inflammation. RES can therefore be valuable in the development of new anti-atherosclerotic agents.
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نویسندگان مقاله geng ruei چنگ | geng ruei chang
department of veterinary medicine, national chung hsing university, 250 kuo kuang road, taichung, taiwan, 40227, r.o.c|division of residual control, agricultural chemicals and toxic substance research institute, council of agriculture, 11 guangming road, wufeng, taichung 41358, taiwan, roc


po lin chen | po lin chen
department of veterinary medicine, national chung hsing university, 250 kuo kuang road, taichung, taiwan, 40227, r.o.c


po hsun hou | po hsun hou
department of veterinary medicine, national chung hsing university, 250 kuo kuang road, taichung, taiwan, 40227, r.o.c|department of psychiatry, taichung veterans general hospital, 160 chung-kang road, taichung, taiwan, 40705, r.o.c


فرانک chiahung mao | frank chiahung mao
department of veterinary medicine, national chung hsing university, 250 kuo kuang road, taichung, taiwan, 40227, r.o.c
نشانی اینترنتی http://ijbms.mums.ac.ir/article_6043.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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