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Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۱۱، صفحات ۱۱۱۲-۱۱۱۷
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عنوان انگلیسی Interactions of smoking with rs833061 polymorphism on the risk of non-alcoholic fat liver disease in Hubei Han population: a preliminary case–control study
چکیده انگلیسی مقاله Objective(s):Vascular endothelial growth factor (VEGF) has biological actions on energy homeostasis, inflammation and insulin resistance. The present study aimed to investigate the association between VEGF -460 T/C (rs833061), and +936 C/T (rs3025039) polymorphism and risk of non-alcohol fatty liver disease (NAFLD) in Hubei Han population and to further explore the interactions of smoking with rs833061 and rs3025039. Materials and Methods:341 healthy controls and 246 cases were recruited. Two variants, rs833061 and rs3025039, were genotyped by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). The unconditional logistic regression (ULR) was performed to assess the association of the two variants with risk of NAFLD. Gene-environment interactions on the risk of NAFLD were preliminarily explored by generalized multifactor dimensionality reduction (GMDR) and further confirmed by ULR methods. Results:After adjusting for covariates, increased risk of NAFLD was observed in patients carrying CT/CC genotypes in rs833061 and rs3025039 (ORa=1.80, 95% confidence interval (CI): 1.51, 2.36, Pa=0.000; ORa=1.89, 95% CI: 1.41, 2.82, Pa=0.000, respectively). Interaction of smoking with rs833061 was found by GMDR, with maximum prediction accuracy (67.91%) and a maximum cross-validation consistency (10/10). ULR method confirmed that, smoking-positive patients with genotype CT/CC had 4.93 times risk of NAFLD compared to smoking-negative participants with genotype TT (ORadda=4.93, 95% CI:2.91, 8.54, Padda=0.000), which further confirmed synergistic effects. Conclusion: The results indicated that both rs833061 and rs3025039 are associated with NAFLD risk. Furthermore, rs833061 is likely to have an interaction with smoking, and they have synergistic effects on risk of NAFLD in Hubei Han population.
کلیدواژه‌های انگلیسی مقاله Interactions, NAFLD, Polymorphisms, Smoking, VEGF
نویسندگان مقاله pengbo wu | pengbo wu
department of gastroenterology, renmin hospital of wuhan university, jiefang road, wuhan, china


yonglong hua | yonglong hua
department of gastroenterology, renmin hospital of tongcheng, minzhu road 120, hubei, china


shiyun tan | shiyun tan
department of gastroenterology, renmin hospital of wuhan university, jiefang road, wuhan, china


ming li | ming li
department of gastroenterology, renmin hospital of wuhan university, jiefang road, wuhan, china


shu yongxiang | shu yongxiang
department of gastroenterology, renmin hospital of wuhan university, jiefang road, wuhan, china


گیو fang | guo fang
department of gastroenterology, renmin hospital of wuhan university, jiefang road, wuhan, china
نشانی اینترنتی http://ijbms.mums.ac.ir/article_6050.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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