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Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۱۰، صفحات ۱۰۱۴-۱۰۱۹
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عنوان انگلیسی Auraptene consolidates memory, reverses scopolamine-disrupted memory in passive avoidance task, and ameliorates retention deficits in mice
چکیده انگلیسی مقاله Objective(s): Auraptene (7-geranyloxycoumarin) (AUR), from Citrus species has shown anti-inflammatory, neuroprotective, and acetylcholinesterase (AChE) and beta-secretase inhibitory effects. Scopolamine is a nonselective muscarinic receptor antagonist which causes short-term memory impairments and is used for inducing animal model of Alzheimer’s disease (AD). This research aimed to investigate the effect of AUR on scopolamine-induced avoidance memory retention deficits in step-through task in mice. Materials and Methods: The effect of four-day pre-training injections of AUR (50, 75, and 100 mg/kg, subcutaneous (SC)) and scopolamine (1 mg/kg, IP), and their co-administration on avoidance memory retention in step-through passive avoidance task, was investigated by measuring the latency to enter to the dark chamber. Results:Pre-training administration of AUR caused significant increase in step-through latency in comparison with control group, 48, 96, and 168 hr after training trial. The findings of this study showed that scopolamine (1 mg/kg, IP, for four consecutive days) impaired passive avoidance memory retention compared to saline-treated animals. Step-through passive avoidance task results showed that AUR markedly reversed scopolamine-induced avoidance memory retention impairments, 24 and 168 hr after training trial in step-through task. Conclusion: Results from co-administration of AUR and scopolamine showed that AUR reversed scopolamine-induced passive avoidance memory retention impairments.
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نویسندگان مقاله کاوه تبریزیان | kaveh tabrizian
department of pharmacology and toxicology, faculty of pharmacy, zabol university of medical sciences, zabol, iran|medicinal plants research center, zabol university of medical sciences, zabol, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زابل (Zabol university of medical sciences)

نجمه سادات یعقوبی | najmeh sadat yaghoobi
department of pharmacology and toxicology, faculty of pharmacy, zabol university of medical sciences, zabol, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زابل (Zabol university of medical sciences)

مهرداد ایرانشاهی | mehrdad iranshahi
biotechnology research center and school of pharmacy, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

جعفر شهرکی | jafar shahraki
department of pharmacology and toxicology, faculty of pharmacy, zabol university of medical sciences, zabol, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زابل (Zabol university of medical sciences)

رامین رضایی | ramin rezaee
department of physiology and pharmacology, school of medicine, north khorasan university of medical sciences, bojnurd, iran


محمود هاشمزایی | mahmoud hashemzaei
department of pharmacology and toxicology, faculty of pharmacy, zabol university of medical sciences, zabol, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زابل (Zabol university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_5466.html
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