این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۱۰، صفحات ۱۰۳۴-۱۰۴۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Oxidative stress, biochemical alterations, and hyperlipidemia in female rats induced by lead chronic toxicity during puberty and post puberty periods
چکیده انگلیسی مقاله Objective(s):Lead (Pb) is a toxic metal inducing many destructive effects leading to a broad range of physiological, biochemical, and neurological dysfunctions in humans and laboratory animals. Materials and Methods: Here, we investigated the effect of chronic exposure to Pb (50 mg/l) on oxidative stress, hepatotoxicity, nephrotoxicity, and lipid profile of two different age groups of female rats treated with Pb from delivery until puberty period (40 days, Pb40) and post puberty period (65 days, Pb65). Results: Our results clearly show that the administration of Pb produces oxidative damage in liver and kidney, as strongly suggested by the significant increase in TBARS, decrease in total SH, and the alteration of SOD activity. Elevation in liver function biomarkers, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and reduction in total protein (liver and plasma) and albumin are evidence of perturbations of liver synthetic function. In young Pb-treated group, Pb-induced nephropathy was more pronounced by the increase in the levels of creatinine, urea, and uric acid. However, hyperlipidemia was evident for both Pb-exposed groups leading to a potential risk for cardiovascular diseases and atherosclerosis. Conclusion: It is concluded that Pb induces metabolic and oxidative disturbances depending on the age of the animals, which are not negligible.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله عنابی alya | annabi alya
laboratory of aggression physiology and endocrine metabolic studies, department of biology, faculty of sciences, tunis, tunisia


dhouib bini ines | dhouib bini ines
laboratory of aggression physiology and endocrine metabolic studies, department of biology, faculty of sciences, tunis, tunisia


lasram montassar | lasram montassar
laboratory of aggression physiology and endocrine metabolic studies, department of biology, faculty of sciences, tunis, tunisia


غربی najoua | gharbi najoua
laboratory of aggression physiology and endocrine metabolic studies, department of biology, faculty of sciences, tunis, tunisia


el fazâa saloua | el fazâa saloua
laboratory of aggression physiology and endocrine metabolic studies, department of biology, faculty of sciences, tunis, tunisia
نشانی اینترنتی http://ijbms.mums.ac.ir/article_5469.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Short Communications
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات