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Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۸، صفحات ۸۲۷-۸۳۱
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عنوان انگلیسی Squid ink polysaccharide reduces cyclophosphamide-induced testicular damage via Nrf2/ARE activation pathway in mice
چکیده انگلیسی مقاله Objective(s):Cyclophosphamide (CP) toxicity on testis was hampered by squid ink polysaccharide (SIP) via restoration of antioxidant ability in our previous investigations. This study investigated roles of Nrf2/ARE signal pathway in testis of treated mice. Materials and Methods: Male Kunming mice were employed to undergo treatment with SIP and/or CP. Protein levels of Nrf2, keap-1, histone deacetylase 2 (HDAC2), quinone oxidoreductase 1 (NQO-1), and heme oxygenase 1 (HO-1) and phosphorylation level of protein kinase C (PKC) in testis were evaluated by Western blotting. Results: Data showed that SIP elevated expressions of NQO-1 and HO-1 genes, two downstream target molecules of Nrf2, via activating Nrf2 to play preventive roles on CP-treated testis, and further discovered that upstream regulators of Nrf2, keap-1, HDAC2, and PKC, were concerned with the regulation of Nrf2. Conclusion: These results suggest that SIP could effectively weaken CP-associated testicular damage via Nrf2/ARE signal pathway.
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نویسندگان مقاله xiaoyan le | xiaoyan le
college of science, guangdong ocean university, zhanjiang, china


ping luo | ping luo
college of science, guangdong ocean university, zhanjiang, china


yipeng gu | yipeng gu
college of science, guangdong ocean university, zhanjiang, china


yexing تایو | yexing tao
college of science, guangdong ocean university, zhanjiang, china


huazhong liu | huazhong liu
college of science, guangdong ocean university, zhanjiang, china
نشانی اینترنتی http://ijbms.mums.ac.ir/article_4735.html
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Short Communications
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