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Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۶، صفحات ۵۵۵-۵۶۲
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چکیده فارسی مقاله
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عنوان انگلیسی Gardenia jasminoides extracts and gallic acid inhibit lipopolysaccharide-induced inflammation by suppression of JNK2/1 signaling pathways in BV-2 cells
چکیده انگلیسی مقاله Objective(s): Gardenia jasminoides Ellis (GJ, Cape Jasmine Fruit, Zhi Zi) has been traditionally used for the treatment of infectious hepatitis, aphthous ulcer, and trauma; however, the direct evidence is lacking. Materials and Methods:We investigated the effect of the GJ extract(GJ) and gallic acid (GA) on lipopolysaccharide (LPS) induced inflammation of BV-2 microglial cells and acute liver injury in Sprague-Dawley (SD) rats. Results:Our results showed that the GJ extract and GA reduced LPS-induced nitric oxide (NO), interleukin (IL)-1, IL-6, reactive oxygen species (ROS), and prostaglandin (PGE2) production in BV-2 cells. The GJ extract and GA significantly decreased serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in LPS-treated rats. Furthermore, the water extract, but not the ethanol extract, of the GJ dose-dependently inhibited LPS-induced JNK2/1 and slightly p38 mitogen-activated protein kinases (MAPK), and cyclooxygenase-2 (COX-2) expression in BV-2 cells. Conclusion:Taken together, these results indicate that the protective mechanism of the GJ extract involves an antioxidant effect and inhibition of JNK2/1 MAP kinase and COX-2 expressions in LPS-induced inflammation of BV-2 cells.
کلیدواژه‌های انگلیسی مقاله BV-2 cell, Gardenia jasminoides, MAPKs, NO, ROS
نویسندگان مقاله wen هانگ lin | wen hung lin
department of technology management, chung hua university, hsinchu, taiwan


heng هانگ kuo | heng hung kuo
department of finance, chung hua university, hsinchu, taiwan


li hsing ho | li hsing ho
department of technology management, chung hua university, hsinchu, taiwan


ming لنگ tseng | ming lang tseng
department of biotechnology, yuanpei university, hsinchu, taiwan


an ci siao | an ci siao
office of physical education, chung hua university hsinchu, taiwan


چنگ tsen هانگ | chang tsen hung
department of health and leisure management, yuanpei university, hsinchu, taiwan


kee چینگ راستین jeng | kee ching jeng
department of medical research, tungs’ taichung metro harbor hospital, taichung, taiwan


chien wei hou | chien wei hou
office of physical education, chung hua university hsinchu, taiwan
نشانی اینترنتی http://ijbms.mums.ac.ir/article_4529.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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