این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۶، صفحات ۶۰۴-۶۰۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The preventive effects of dexmedetomidine against intestinal ischemia-reperfusion injury in Wistar rats
چکیده انگلیسی مقاله Objective(s): Intestinal ischemia-reperfusion is a major problem, which may lead to multiorgan failure and death. The aim of this study was to evaluate the protective effects of dexmedetomidine on cell proliferation, antioxidant system, cell death, and structural integrity in intestinal injury induced by ischemia-reperfusion in rats. Materials and Methods: Animals were randomized into three groups: group A, sham-operated or control; group B, intestinal ischemia/reperfusion (IR); and group C, intestinal IR pretreated with 50 μg of dexmedetomidine. Intestine tissue was collected from all rats 30 min after desufflation, and fresh frozen for histological and biochemical evaluation. Results: The intestinal tissue of group B rats showed a significant decrease in the antioxidant enzyme activities. However, these enzyme activities were improved by the administration of dexmedetomidine. Inhibiting the protein expression of MCP7, PAR2, P-JAK, P-STAT1, and P-STAT3 proved the protective effect of dexmedetomidine. The immunohistochemical staining revealed its protective effect by maintaining the normal structural integrity, less caspase-3 immuno reactivity, and increased cell proliferation count in the intestinal tissues. Conclusions: Intraperitoneal injection of dexmedetomidine significantly protected intestine IR injury in rats by inhibiting the inflammatory response, intestinal epithelial apoptosis, and maintaining structural integrity of intestinal cells.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله xue کانگ زانگ | xue kang zhang
department of anesthesiology, first affiliated hospital of nanchang university, nanchang, jiangxi 330006, china


محمد بن همام رییس کنفدراسیون ping zhou | xiao ping zhou
grade 2012 of medical department of graduate school, nanchang university, nanchang, jiangxi 330006, china


qin زانگ | qin zhang
department of anesthesiology, first affiliated hospital of nanchang university, nanchang, jiangxi 330006, china


feng zhu | feng zhu
intensive care unit icu , first affiliated hospital of nanchang university, nanchang, jiangxi 330006, china
نشانی اینترنتی http://ijbms.mums.ac.ir/article_4539.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات