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Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۵، صفحات ۴۷۸-۴۸۴
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عنوان انگلیسی Ferulic acid protects PC12 neurons against hypoxia by inhibiting the p-MAPKs and COX-2 pathways
چکیده انگلیسی مقاله Objective(s):Hypoxia induces cellular oxidative stress that is associated with neurodegenerative diseases. Here, the protective effects of ferulic acid (FA) on hypoxia-induced neurotoxicity in PC12 cells were evaluated. Materials and Methods:We investigated the effect of FA on PC12 cells subjected to hypoxia stress, in vitro. Results:FA increased cell viability, prevented membrane damage (LDH release), scavenged free radicals, increased superoxide dismutase (SOD) activity, and attenuated the elevation of intracellular free Ca2+, lipid peroxidation, apoptosis (evaluated by TUNEL staining) and PGE2 production in hypoxia-stressed PC12 cells. MAPKs were activated during hypoxia. FA reduced p-p38 MAPK, caspase-3, and COX-2 activation which correlated well with diminished LDH release in PC12 cells under hypoxia. Furthermore, FA reduced lipid peroxidation in PC12 cells subjected to hypoxia. Conclusion:Taken together, these results indicate that FA antioxidant effects could partly be involved in inhibition of p38 MAPK pathway and apoptosis through scavenging ROS in hypoxia-stressed PC12 cells.
کلیدواژه‌های انگلیسی مقاله Caspase-3, Ferulic acid, Hypoxia, MAPKs, ROS
نویسندگان مقاله wen chieh lin | wen chieh lin
department of optometry, yuanpei university, hsinchu, taiwan


yu fen peng | yu fen peng
department of physical education office, yuanpei university, hsinchu, taiwan


chien wei hou | chien wei hou
department of biotechnology, yuanpei university, hsinchu, taiwan
نشانی اینترنتی http://ijbms.mums.ac.ir/article_4411.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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