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Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۵، صفحات ۵۱۴-۵۱۹
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عنوان انگلیسی The reduction of aorta histopathological images through inhibition of reactive oxygen species formation in hypercholesterolemia rattus norvegicus treated with polysaccharide peptide of Ganoderma lucidum
چکیده انگلیسی مقاله Objective(s):Atherosclerosis is chronic inflammatory process triggered by oxidative stress. Oxidative stress can increase hydrogen peroxide (H2O2)level, which induce atherosclerosis through the processes such as formation of perivascular adipose tissue (PVAT), foam cells, and atherosclerotic plaque. Antioxidant is needed to control negative effects of oxidative stress. One source of antioxidant, which has potential to be developed, is PsP from Ganoderma lucidum. This study aims to prove the effect of PsP in decreasing H2O2, PVAT, foam cells and atherosclerotic plaque. Materials and Methods: This study was experimental randomized post-test with control group design using 25 Rattus norvegicus Wistar strain rats. Rats were divided into 5 groups (negative control, positive control, and 3 high-fat diet group with PsP dose: 50, 150, 300 mg/kgBW). Measured parameters were H2O2, PVAT, foam cell, and atherosclerotic plaques. Analysis of variance (ANOVA) was used for statistical analysis, followed by post hoc test. Results: Mean H2O2 levels, PVAT thickness, foam cell numbers, and atherosclerotic plaque were low in negative control group. ANOVA showed that PsP significantly (P< 0.05) reduced H2O2 levels, PVAT thickness, foam cells numbers and atherosclerotic plaque width. Conclusion: PsP dose of 300 mg/kgBW has the most significant effect in decreasing H2O2 levels, PVAT thickness, number of foam cells, and atherosclerotic plaque width. Based on the results of this research, PsP can be recommended as antioxidant to control pathogenesis of atherosclerosis.
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نویسندگان مقاله titin andri wihastuti | titin andri wihastuti
department of biomedical, faculty of medicine, brawijaya university, malang, indonesia


djanggan sargowo | djanggan sargowo
department of cardiology, faculty of medicine, brawijaya university, malang, indonesia


teuku heriansyah | teuku heriansyah
department of cardiology, faculty of medicine, syiah kuala university, aceh, indonesia


یاسمین eka عزیزه | yasmin eka aziza
bachelor programme, faculty of medicine, brawijaya university, malang, indonesia


dyah puspitarini | dyah puspitarini
bachelor programme, faculty of medicine, brawijaya university, malang, indonesia


amalina نور iwana | amalina nur iwana
bachelor programme, faculty of medicine, brawijaya university, malang, indonesia


lucky astrida evitasari | lucky astrida evitasari
bachelor programme, faculty of medicine, brawijaya university, malang, indonesia
نشانی اینترنتی http://ijbms.mums.ac.ir/article_4416.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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