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Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۵، صفحات ۵۲۶-۵۲۸
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عنوان انگلیسی The RETN gene rs1862513 polymorphism as a novel predisposing marker for familial Acne vulgaris in a Pakistani population
چکیده انگلیسی مقاله Resistin (RETN), recently found to be relevant to inflammation and inflammatory disorders. We, therefore, aimed to investigate the potential role of RETN gene polymorphism in pathogenesis of acne vulgaris with familial history. We investigated the RETN-420C/G polymorphism in 180 patients with acne vulgaris and 180 healthy individuals in a case-control association analysis. In this study, we also investigated the heritability of the RETN susceptible allele from 140 trio families with acne affected offspring. The genotyping was performed by polymerase chain reaction and direct DNA sequencing.The RETN-420C/G polymorphism was significantly associated with acne in patients compared with healthy controls (P=0.014). The minor allele G at -420 was more prevalent in cases vs. controls (P=0.002). The RETN-420C/G polymorphism was significantly associated with severity of acne vulgaris in patients (P=0.0097). The results of a transmission disequilibrium test revealed a significant association between the RETN-420C/G polymorphism and acne vulgaris (P< 0.001). For the first time in the literature, to our knowledge, we demonstrate a significant association of the RETN-420C/G functional polymorphism with familial acne vulgaris.
کلیدواژه‌های انگلیسی مقاله Acne, Association, Gene, Polymorphism, Resistin
نویسندگان مقاله sabir حسین | sabir hussain
department of biosciences, comsats institute of information technology, islamabad-46000, pakistan


احمد فراز | ahmad faraz
department of surgery, government post graduate medical institute, lady reading hospital, peshawar, pakistan


طاهر اقبال | tahir iqbal
department of internal medicine, shifa college of medicine, shifa international hospital, h-8 4, islamabad, pakistan
نشانی اینترنتی http://ijbms.mums.ac.ir/article_4419.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Research Brief
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