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Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۴، صفحات ۳۵۶-۳۶۳
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عنوان انگلیسی Neuroprotective effect of p-coumaric acid in rat model of embolic cerebral ischemia
چکیده انگلیسی مقاله Objective(s): Stroke poses a crucial risk for mortality and morbidity. Our study aimed to investigate the effect of p-coumaric acid on focal cerebral ischemia in rats. Material and Methods: Rats were randomly divided into four groups, namely Group I (control rats), Group II (ischemia rats), Group III (6 hr ischemia + p-coumaric acid rats) and Group IV (24 hr ischemia + p-coumaric acid rats). Cerebral ischemia was induced via intraluminal monofilament occlusion model. In all groups, the brain was removed after the procedure and rats were sacrificed. Malondialdehyde, superoxide dismutase and nuclear respiratory factor-1 were measured in the ischemic hemisphere. The histopathological changes were observed in the right hemisphere within the samples. Functional assessment was performed for neurological deficit scores. Results: Following the treatment, biochemical factors changed significantly. Histopathologically, it was shown that p-coumaric acid decreased the oxidative damage. The neurological deficit scores of p-coumaric acid-treated rats were significantly improved after cerebral ischemia. Conclusion:Our results showed that p-coumaric acid is a neuroprotective agent on account of its strong anti-oxidant and anti-apoptotic features. Moreover, p-coumaric acid decreased the focal ischemia. Extra effort should be made to introduce p-coumaric acid as a promising therapeutic agent to be utilized for treatment of human cerebral ischemia in the future.
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نویسندگان مقاله مصطفی guven | mustafa guven
department of neurosurgery, faculty of medicine, çanakkale onsekiz mart university, çanakkale, turkey


adem bozkurt آراس | adem bozkurt aras
department of neurosurgery, faculty of medicine, çanakkale onsekiz mart university, çanakkale, turkey


tarik akman | tarik akman
department of neurosurgery, faculty of medicine, çanakkale onsekiz mart university, çanakkale, turkey


halil مرات sen | halil murat sen
department of neurosurgery, faculty of medicine, çanakkale onsekiz mart university, çanakkale, turkey


adile ozkan | adile ozkan
department of neurosurgery, faculty of medicine, çanakkale onsekiz mart university, çanakkale, turkey


عثمان salis | osman salis
department of medical biochemistry, faculty of medicine, ondokuz mayıs university, samsun, turkey


ابراهیم sehitoglu | ibrahim sehitoglu
department of pathology, faculty of medicine, recep tayyip erdoğan university, rize, turkey


yildiray kalkan | yildiray kalkan
department of histology amp;amp; embryology, faculty of medicine, recep tayyip erdoğan university, rize, turkey


coskun silan | coskun silan
department of pharmacology, faculty of medicine, çanakkale onsekiz mart university, çanakkale, turkey


مصطفی دنیز | mustafa deniz
department of physiology, faculty of medicine, çanakkale onsekiz mart university, çanakkale, turkey


مرات cosar | murat cosar
department of neurosurgery, faculty of medicine, çanakkale onsekiz mart university, çanakkale, turkey
نشانی اینترنتی http://ijbms.mums.ac.ir/article_4284.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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