این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۴، صفحات ۴۱۲-۴۱۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Nephroprotective potential of Graptophyllum pictum against renal injury induced by gentamicin
چکیده انگلیسی مقاله Objective(s):To evaluate the effect of Graptophyllum pictum on lipid peroxidation and tissue antioxidant enzymes in liver and kidney of gentamicin induced nephrotoxic rats. Materials and Methods: Animals were grouped into 6: Group 1 received gum acacia, Group 2 received G. pictum ethanol extract (300 mg/kg), Group 3 received gentamicin, Groups 4, 5, 6 received gentamicin along with G. pictum at 300, 150, 75 mg/kg, respectively. Nephroprotective activity was evaluated by measuring thiobarbituric acid-reactive substances (TBARS), biochemical markers Glutathione (GSH), Glutathione-S Transferase(GST), Superoxide dismutase (SOD), Catalase (CAT), serum urea and creatinine levels. Results: Results obtained showed that gentamicin induced nephrotoxic rats exhibited lower activities of biochemical markers and raised levels of TBARS, serum creatinine and urea. Remarkably, after treatment with G. pictum extract, anomalous levels of biochemical markers, lipid peroxidation and serum creatinine were returned to normal. Conclusion: The results propose that G. pictum has nephroprotective effects, and can be a promising natural source against gentamicin induced nephrotoxicity.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله keloth kaitheri srinivasan | keloth kaitheri srinivasan
department of chemistry, shri madhwa vadiraja institute of technology and management, udupi- 574115, india


jessy الیزابت ماتیو | jessy elizabeth mathew
department of pharmaceutical chemistry, manipal college of pharmaceutical sciences, manipal university, manipal-576104, karnataka, india


kerryn یوسف a d سیلوا | kerryn joseph a d silva
department of pharmaceutical chemistry, manipal college of pharmaceutical sciences, manipal university, manipal-576104, karnataka, india


ریچارد lobo | richard lobo
department of pharmacognosy, manipal college of pharmaceutical sciences, manipal university, manipal-576104, karnataka, india


nimmy کومار | nimmy kumar
department of pharmacognosy, manipal college of pharmaceutical sciences, manipal university, manipal-576104, karnataka, india
نشانی اینترنتی http://ijbms.mums.ac.ir/article_4292.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Short Communications
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات