این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۳، صفحات ۲۲۸-۲۳۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Alpha-lipoic acid loaded in chitosan conduit enhances sciatic nerve regeneration in rat
چکیده انگلیسی مقاله Objective(s): To investigate the effect of topical administration of alpha-lipoic acid into chitosan conduit on peripheral nerve regeneration using a rat sciatic nerve transection model. Materials and Methods: Forty five Wistar rats were divided into three experimental groups randomly. A 10-mm gap of sciatic nerve was bridged with a chitosan conduit following surgical preparation and anesthesia. In treatment group, the conduit was filled with 30 µl alpha-lipoic acid (10 mg/kg/bw).It was filled with 30 µl phosphate buffered saline solution in control group. In Sham group sciatic nerve was just exposed. Results: The recovery of nerve function was faster in treatment group than in control, at 4 and 8 weeks after surgery (P-value< 0.05). Conduction velocity was better in treatment group than in control group at 4 and 12 weeks (P-value< 0.05). Recovery index was higher in treatment group than the control group, 8 weeks after surgery (P-value < 0.05). Greater nerve fiber diameter, axon diameter, and myelin sheath thickness were observed in treatment group compared to control group at 8 and 12 weeks after surgery (P-value< 0.05). The immunoreactivity of regenerated axons and myelin sheath in treatment group were far more similar to sham group. Conclusion: Alpha-lipoic acid when loaded in a chitosan conduit could improve transected sciatic nerve regeneration in rat.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله سعید عزیزی | saeed azizi
department of clinical sciences, faculty of veterinary medicine, urmia university, urmia, iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

داریوش حمیدی علمداری | daryoush hamidi alamdari
faculty of medicine, mashhad university of medical sciences, mashhad, iran stem cell amp;amp; regenerative medicine research group, department of clinical biochemistry, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

کیوان امینی | keyvan amini
department of veterinary pathology, western college of veterinary medicine, university of saskatchewan, saskatoon, saskatchewan, canada


عباس رییسی | abbas raisi
department of clinical sciences, faculty of veterinary medicine, lorestan university, khoramabad, iran

سازمان اصلی تایید شده: دانشگاه لرستان (Lorestan university)

محمد عظیم زاده | mohammad azimzadeh
department of clinical sciences, faculty of veterinary medicine, urmia university, urmia, iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_4120.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات