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Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۳، صفحات ۲۴۶-۲۵۱
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عنوان انگلیسی Immunotherapeutic effects of pentoxifylline in type 1 diabetic mice and its role in the response of T-helper lymphocytes
چکیده انگلیسی مقاله Objective(s):Pentoxifylline is an immunomodulatory and anti-inflammatory agent and is used in vascular disorders. It has been shown that pentoxifylline inhibits proinflammatory [d1] cytokines production. The purpose of this study was to investigate the therapeutic effects of pentoxifylline on the treatment of autoimmune diabetes in mice. Materials and Methods: Diabetes was induced by multiple low dose of streptozotocin (MLDS) injection (40 mg/kg/day for 5 consecutive days) in male C57BL/6 mice. After induction of diabetes, mice were treated with pentoxifylline (100 mg/kg/day IP) for 21 days. Blood glucose levels and plasma levels of insulin were measured. Splenocytes were tested for proliferation by MTT test and cytokine production by ELISA. Results: Pentoxifylline treatment prevented hyperglycemia and increased plasma insulin levels in the diabetic mice. Aside from reducing lymphocyte proliferation, pentoxifylline significantly inhibited the production of proinflammatory interleukin 17 (IL-17) as well as interferon gamma (IFN-γ), while increased anti-inflammatory cytokine IL-10 as compared with those in MLDS group (diabetic control group). Conclusion: These findings indicate that pentoxifylline may have therapeutic effect against the autoimmune destruction of the pancreatic beta-cells during the development of MLDS-induced type 1 diabetes in mice.
کلیدواژه‌های انگلیسی مقاله Cytokine, Pentoxifylline, Type 1 diabetes mellitus
نویسندگان مقاله فرین ملکی فرد | farin malekifard
department of microbiology, school of veterinary medicine, urmia university, urmia, iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

نوروز دلیرژ | nowruz delirezh
department of microbiology, school of veterinary medicine, urmia university, urmia, iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

رحیم حب نقی | rahim hobbenaghi
department of pathobiology, school of veterinary medicine, urmia university, urmia, iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

حسن ملکی نژاد | hassan malekinejad
department of pharmacology amp;amp; toxicology, school of veterinary medicine, urmia university, urmia, iran

سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_4125.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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