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Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۲، صفحات ۲۰۵-۲۱۱
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عنوان انگلیسی An in vivo and in vitro investigation on hepatoprotective effects of Pimpinella anisum seed essential oil and extracts against carbon tetrachloride-induced toxicity
چکیده انگلیسی مقاله Objective(s): Protective effects of different extracts and essential oil from Pimpinella anisum L. seeds were examined against carbon tetrachloride (CCl4)-induced toxicity. The parameters such as serum transaminases, lactate dehydrogenase activity, hepatic glutathione content, liver lipid peroxidation and histopathological changes of liver were assessed as toxicity markers. In the in vitro model of this study, markers such as cell viability, cellular reduced and oxidized glutathione and lipid peroxidation in HepG2 cells were evaluated. Materials and Methods:Human liver cancer cell line HepG2 and male Sprague-Dawley rats were treated with extracts and essential oil, and markers of hepatotoxicity were investigated. Results: The data revealed that the n-hexane extract, effectively attenuated CCl4‑induced toxicity in both in vitro and in vivo models in current investigation. Conclusion: As the oxidative stress markers were ameliorated, it might be concluded that anise seed possesses protective effects probably due to its antioxidant constituents.
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نویسندگان مقاله اکرم جمشیدزاده | akram jamshidzadeh
medicinal plants processing research center, shiraz university of medical sciences, shiraz, iran department of pharmacology and toxicology, school of pharmacy, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

رضا حیدری | reza heidari
pharmaceutical sciences research center, shiraz university of medical sciences, shiraz, iran gerash faculty of paramedical sciences, shiraz university of medical sciences, gerash, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

مجتبی رزمجو | mojtaba razmjou
department of pharmacology and toxicology, school of pharmacy, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

فروزان کریمی | forouzan karimi
department of pharmacology and toxicology, school of pharmacy, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

محمود رضا معین | mahmood reza moein
medicinal plants processing research center, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

امید فرشاد | omid farshad
shiraz university of medical sciences, international branch, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

امین رضا اکبری زاده | amin reza akbarizadeh
pharmaceutical sciences research center, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

محمدرضا هوشنگی شایسته | mohammad reza houshangi shayesteh
shiraz university of medical sciences, international branch, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_4026.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Short Communications
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