این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۱، صفحات ۸-۱۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Apoptotic and proliferative activity of mouse gastric mucosa following oral administration of fumonisin B1
چکیده انگلیسی مقاله Objective(s):Fumonisins are a group of toxic and carcinogenic mycotoxins, which contaminate the grains and their products. The aim of this study was to examine the apoptotic and proliferative activity of mouse gastric mucosa following administration of fumonisin B1 (FB1). Materials and Methods: Twenty-nine female mice divided into treatment (n=15) and control (n=14) groups. The treatment group received FB1 (150 mg/kg diet) for 16 weeks. The gastric atrophy was allocated using grading criteria modeled on the updated Sydney System. Immunohistochemistry studies were performed for evaluation of apoptosis and proliferative activity in gastric mucosa. Results: Mild to moderate gastric atrophy were observed in microscopic findings of the gastric mucosa in treated animals (P< 0.05). Number of parietal cells significantly decreased in the treatment group in comparison with the control (P< 0.05). Treatment with FB1 for 16 weeks significantly reduced both gastric mucosa height and mitotic index in the gastric glands (P< 0.05). TUNEL- and Bax-labeled positive cell numbers significantly increased in the FB1-treated group compared to the control (P< 0.05). In addition, proliferative activity of gastric glands in the treated group was significantly lower than the control (P< 0.05). Conclusion: Oral administration of FB1 caused atrophy in gastric mucosa both via increasing of apoptosis and suppressing the mitotic activity of these cells.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله علی محمد علیزاده | ali mohammad alizadeh
1 cancer research center, tehran university of medical sciences, tehran, iran 2 cancer model research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فهیمه محمد قاسمی | fahimeh mohammadghasemi
cellular and molecular research center, faculty of medicine, guilan university of medical sciences, rasht, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)

کاظم زنده دل | kazem zendehdel
cancer research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

زهرا کامیابی مقدم | zahra kamyabi moghaddam
department of pathology, faculty of veterinary medicine, tehran university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

عباس توسلی | abbas tavassoli
department of pathology, faculty of veterinary medicine, tehran university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

فاطمه امینی نجفی | fatemeh amini najafi
department of pathology, faculty of veterinary medicine, tehran university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

علیرضا خسروی | alireza khosravi
medical parasitology and mycology department, school of medicine, tehran university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_3880.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات