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Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۱، صفحات ۷۲-۷۹
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عنوان انگلیسی Microinjection of calcitonin in midbrain periaqueductal gray attenuates hyperalgesia in a chronic constriction injury rat model
چکیده انگلیسی مقاله Objective(s): As heat, pain is one of the most common clinical symptoms. Generally, calcitonin (CT) is prescribed as an analgesic agent for the treatment of pain, especially for the pain caused by osteoporosis or primary and metastatic bone tumor. However, the detailed mechanism remains unknown.Materials and Methods: In this study, chronic constriction injury (CCI) rat model was created, and hot plate test and von frey filaments test were employed to evaluate thermal withdrawal latency (TWL) and mechanical withdrawal threshold (MWT), respectively. Immunohistochemistry staining and western blot analyses were used to assess the distribution and expression of calcitonin receptor (CT-R) in the midbrain periaqueductal gray (PAG), which was a pivotal site in the modulatory system for the endogenous pain.Results: The TWL and MWT before the surgery (19.6±1.19 sec) were significantly longer than that at day 2 (12.5±1.60 sec), and day 14 (7.75±0.89 sec) (P< 0.01; P< 0.01), respectively. The TWL and MWT at day 14 were significantly increased compared to that at day 7 after microinjection of salmon calcitonin (sCT) with different doses. Interestingly, the expression of CT-R was up-regulated in neuropathic pain. Furthermore, the expression of CT-R was significantly up-regulated and algesia was remarkably relieved when CT was microinjected into PAG.Conclusion: These results suggested that an increased CT-R might be associated with hyperalgesia in CCI rat, and CT had a potent antinociceptive effect by the up-regulation of CT-R in the PAG. Thus, it might provide a potential approach for the treatment of bone pain.
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نویسندگان مقاله zongpeng li | zongpeng li
operatiom room, linyi people’s hospital, linyi 276000, china


zong امتیاز | zong gao
neurosurgery department, affiliated hospital of shandong university of traditional chinese medicine, jinan 250011, china


shufa li | shufa li
endocrinology department, linyi people’s hospital, linyi 276000, china


yuanyuan زانگ | yuanyuan zhang
endocrinology department, linyi people’s hospital, linyi 276000, china


lizhi xing | lizhi xing
endocrinology department, linyi people’s hospital, linyi 276000, china


lanju زانگ | lanju zhang
endocrinology department, linyi people’s hospital, linyi 276000, china


guijie ma | guijie ma
endocrinology department, linyi people’s hospital, linyi 276000, china


xinbo zhao | xinbo zhao
endocrinology department, linyi people’s hospital, linyi 276000, china


mingtao شایو | mingtao shao
surgery department, linyi people’s hospital, linyi 276000, china
نشانی اینترنتی http://ijbms.mums.ac.ir/article_4606.html
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زبان مقاله منتشر شده en
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