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Iranian Journal of Basic Medical Sciences، جلد ۱۷، شماره ۱۰، صفحات ۷۴۷-۷۵۲
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عنوان انگلیسی Oxytocin alleviates cisplatin-induced renal damage in rats
چکیده انگلیسی مقاله Objective(s):The purpose of the present study was to investigate the protective effect of oxytocin on cisplatin (CP)-induced renal damage in rats. Materials and Methods: Fourteen adult Sprague Dawley rats, weighing 200 to 210, were administered by cisplatin (CP, 2 mg/kg/day) twice a week for five weeks. Then, they were randomly divided into two groups and treated with either saline (1 ml/kg/day) or OT (200 µg/kg/day) for five weeks. Seven rats served as control group. At the end of the treatment period, animals were sacrificed and their kidneys were assessed histologically. In addition, C-reactive protein (CRP), TGF-β and Akt expression were evaluated immunohistochemically. Results:Both tubules and glomeruli were found to be severely damaged with marked medullary tubulo-interstitial inflammation due to chronic cisplatin exposure, particularly in the saline-treated group (Group 1) compared to control group. Oxytocin treatment spared renal tissue significantly by suppressing CRP and TGF-β, and enhancing Akt expression. Conclusion: We conclude that renal damage due to cisplatin toxicity was prevented to a great extent by the anti-inflammatory effect of oxytocin.
کلیدواژه‌های انگلیسی مقاله Akt, Cisplatin toxicity, CRP, kidney, Oxytocin TGF-β
نویسندگان مقاله oytun erbas | oytun erbas
gaziosmanpasa university faculty of medicine, department of physiology, tokat turkey


huseyin آنیل korkmaz | huseyin anil korkmaz
izmir dr behcet uz pediatric medicine and surgery training and research hospital, pediatric endocrinology clinic, izmir, turkey


فتیحه oltulu | fatih oltulu
ege university school of medicine, department of histology and embryology, izmir, turkey


hüseyin aktug | hüseyin aktug
ege university school of medicine, department of histology and embryology, izmir, turkey


altug yavasoglu | altug yavasoglu
ege university school of medicine, department of histology and embryology, izmir, turkey


levent akman | levent akman
ege university school of medicine, department of gynecology and obstetrics, izmir, turkey


volkan سولماز | volkan solmaz
gaziosmanpasa university faculty of medicine, department of neurology, tokat, turkey


دیلک taskiran | dilek taskiran
ege university faculty of medicine, department of physiology, izmir, turkey
نشانی اینترنتی http://ijbms.mums.ac.ir/article_3448.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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