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Iranian Journal of Basic Medical Sciences، جلد ۱۷، شماره ۱۰، صفحات ۷۵۳-۷۵۹
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عنوان انگلیسی Gabapentin enhances anti-nociceptive effects of morphine on heat, cold, and mechanical hyperalgesia in a rat model of neuropathic pain
چکیده انگلیسی مقاله Objective(s):Neuropathic pain is caused by lesions or diseases affecting the somatosensory system and often responds poorly to typical medications. In this study, we evaluated anti-nociceptive effects of morphine, gabapentin and their combination on heat hyperalgesia, cold and mechanical allodynia in chronic constriction injury (CCI) model of neuropathic pain in rats. Materials and Methods: Morphine (2, 4 and 8 mg/kg) and gabapentin (5, 10 and 20 mg/kg) were administered either alone or in combination (morphine 2 mg/kg and gabapentin 5 mg/kg). Results:Our results showed that morphine and gabapentin alone produce anti-nociceptive effects at higher doses (morphine 4 and 8 mg/kg and gabapentin 10 and 20 mg/kg) whereas their combination resulted in better analgesia at lower doses as compared to other treatment groups (morphine 2 mg/kg or gabapentin 5 mg/kg). Conclusion: These findings suggest that gabapentin potentiates the analgesic effects of morphine in the chronic constriction injury (CCI) model of neuropathic pain and combination of these drugs may be considered as a beneficial treatment for neuropathic pain.
کلیدواژه‌های انگلیسی مقاله Gabapentin, Hyperalgesia, Neuropathic pain, Morphine
نویسندگان مقاله غلامعلی حمیدی | gholam ali hamidi
physiology research center, kashan university of medical sciences, kashan. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کاشان (Kashan university of medical sciences)

مجید جعفری ثابت | majid jafari sabet
department of pharmacology, school of medicine, aja university of medical sciences, tehran, iran


علیرضا عابد | alireza abed
department of pharmacology, school of medicine, kashan university of medical sciences, kashan. iran 5 department of pharmacology and toxicology, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

اعظم مصداقی نیا | azam mesdaghinia
physiology research center, kashan university of medical sciences, kashan. iran .department of pharmacology, school of medicine, kashan university of medical sciences, kashan. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کاشان (Kashan university of medical sciences)

محدثه محلوجی | mohadeseh mahlooji
physiology research center, kashan university of medical sciences, kashan. iran .department of pharmacology, school of medicine, kashan university of medical sciences, kashan. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کاشان (Kashan university of medical sciences)

حمیدرضا بنفشه | hamid reza banafshe
department of addiction studies, school of medicine, kashan university of medical sciences, kashan. iran physiology research center, kashan university of medical sciences, kashan. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کاشان (Kashan university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_3449.html
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