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Iranian Journal of Basic Medical Sciences، جلد ۱۷، شماره ۱۰، صفحات ۷۶۰-۷۶۶
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عنوان انگلیسی Enhancement of transdermal delivery of ibuprofen using microemulsion vehicle
چکیده انگلیسی مقاله Objective(s):The objective of this study was to find a stable microemulsion vehicle for transdermal delivery of ibuprofen to improve the skin permeability. Materials and Methods: Microemulsion was prepared using different sorts of oils, surfactants and co-surfactants. Pseudo-ternary phase diagrams were used to evaluate the microemulsion domain. The effects of oleic acid and surfactant mixture on skin permeation of ibuprofen were evaluated with excised skins. Results: The optimum formulation F3 consisting of 6% oleic acid, 30% Cremophor RH40/Transcutol P (2:1, w/w) and 59% water phase, showed a high permeation rate of 42.98 μg/cm2/hr. The mean droplet size of microemulsion was about 43 nm and no skin irritation signs were observed on the skin of rabbits. Conclusion: These results indicated that this novel microemulsion is a useful formulation for the transdermal delivery of ibuprofen.
کلیدواژه‌های انگلیسی مقاله ibuprofen, Microemulsion, Skin Permeability, Transdermal
نویسندگان مقاله liandong hu | liandong hu
1 college of pharmaceutical sciences, hebei university, baoding, china 2 key laboratory of pharmaceutical quality control of hebei province, hebei university, baoding, china


qiaofeng hu | qiaofeng hu
college of pharmaceutical sciences, hebei university, baoding, china. nbp pharmaceutical company limited, cspc pharmaceutical group limited, shijiazhuang 052165, people’s republic of china


jianxue یانگ | jianxue yang
1 college of pharmaceutical sciences, hebei university, baoding, china.3 nbp pharmaceutical company limited, cspc pharmaceutical group limited, shijiazhuang 052165, people’s republic of china
نشانی اینترنتی http://ijbms.mums.ac.ir/article_3450.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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