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Iranian Journal of Basic Medical Sciences، جلد ۱۷، شماره ۹، صفحات ۶۳۸-۶۴۵
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عنوان انگلیسی Surface protein mutations in chronic hepatitis B patients who received hepatitis B vaccine therapy
چکیده انگلیسی مقاله Objective (s):The aim of this study was to determine the correlation between vaccine therapy and appearance of mutations in hepatitis B surface antigen (HBsAg)-positive chronic hepatitis B virus (HBV) patients. Materials and Methods: 16 patients received the HBV vaccine and another 16 individuals from the control group did not. The surface gene was amplified and directly sequenced from samples prior to vaccination and six months after the third dose. Results:Only one patient lost HBsAg. 48 and 44 amino acid mutations were found before and after vaccine therapy in the vaccine group respectively, 51 of which (55.4%) occurred in immune epitopes: 5 were in B cell, 21 in T helper (Th), and 25 in cytotoxic T-lymphocyte (CTL) epitopes. In the control group, 35 and 41 amino acid substitutions were found before and after therapy, respectively. 32 (42%) of 76 amino acid changes occurred within immune epitopes. There were no differences in age, gender, and duration of chronicity in both patient and control groups in terms of the frequency and the patterns of mutations. Conclusion: In chronic carriers who already had HBsAg variants selected by the host-immune response, any immune stimulation by the vaccine had no effect on the chronic state of these patients or selected any remarkable escape mutants. Newer strategies should be considered based on third generation or the use of DNA vaccines or new adjuvants.
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نویسندگان مقاله مریم دارم | maryam daram
hepatitis b molecular laboratory, department of virology, school of public health, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

قدرت اله منتظری | ghodratollah montazeri
digestive disease research center, shariati hospital, tehran, iran


هادی کریم زاده | hadi karimzadeh
hepatitis b molecular laboratory, department of virology, school of public health, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

رضا ملک زاده | reza malekzadeh
digestive disease research center, shariati hospital, tehran, iran


محمود محمودی | mahmood mahmoodi
department of epidemiology, school of public health, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

زهرا گودرزی | zahra goodarzi
hepatitis b molecular laboratory, department of virology, school of public health, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

حسین کیوانی | hossein keyvani
keyvan virology laboratory, tehran, iran


شهرام دکتر شهرام میرمومن | shahram mirmomen
imam khomeini hospital, tehran, iran


سید موید علویان | seyed moayed alavian
baqiyatallah research center for gastroenterology and liver disease, tehran, iran


میکاییل roggendorf | michael roggendorf
robert-koch-haus virchowstr.179.45147, essen, germany


سید محمد جزایری | seyed mohammad jazayeri
hepatitis b molecular laboratory, department of virology, school of public health, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_3322.html
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