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Iranian Journal of Basic Medical Sciences، جلد ۱۷، شماره ۹، صفحات ۶۹۴-۷۰۱
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عنوان انگلیسی The effects of co-administration of opium and morphine with nicotine during pregnancy on spatial learning and memory of adult male offspring rats
چکیده انگلیسی مقاله Objective(s): Smoking opium/cigarette is a global health concern. The aim of this study was to examine learning and memory of rat male offsprings whose mothers had been exposed to either opium or morphine with nicotine during pregnancy. Materials and Methods: Wistar rats were used for the experiments. In the female rats, opium, morphine and nicotine dependencies were induced by daily injections of drug solution for 10 days before mating. Spatial memory was tested by Morris water maze test in male pups at the postnatal day 60. The duration that took until the rats found the platform in the maze and also their swimming speed were recorded. Results: An increase in the platform finding duration was observed for the pups of dependent mothers in comparison with the control in the training trial (P< 0.05). Prenatal exposure to opium/morphine and nicotine significantly decreased the time spent in the trigger zone to find the hidden platform (P< 0.05) but had no significant effect on the swimming speed in the probe test. However, no significant difference was observed in the learning and memory behavior of offspring whose mothers received morphine, opium, nicotine or the co-administration of either morphine or opium with nicotine. Conclusion: The present study showed that the opium, morphine and nicotine abuse and co-administration of opium/morphine with nicotine during pregnancy may cause deficits in spatial learning of male rat offspring. Based on our data, no synergistic effects of co-drug administration were observed on learning and memory in male rat offspring.
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نویسندگان مقاله غلامرضا سپهری | gholamreza sepehri
neuroscience research center, institute of neuropharmacology, kerman university of medical sciences kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

شهرناز پارسانیا | shahrnaz parsania
neuroscience research center, institute of neuropharmacology, kerman university of medical sciences kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

mousa‐al‐reza حاج زاده | mousa‐al‐reza hajzadeh
mashhad cognitive neuroscience research center and dept. of physiology, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

طاهره حق پناه | tahereh haghpanah
neuroscience research center, institute of neuropharmacology, kerman university of medical sciences kerman, iranreproductive biology and anatomy department, school of medicine, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

وحید شیبانی | vahid sheibani
neuroscience research center, institute of neuropharmacology, kerman university of medical sciences kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

کورس دیوسالار | kouros divsalar
neuroscience research center, institute of neuropharmacology, kerman university of medical sciences kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

شهناز شکرفروش | shahnaz shekarforoush
department of physiology, arsanjan branch, islamic azad university, fars, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

محمدرضا آفرینش | mohammad reza afarinesh
nprc and physiology dept., school of medicine, shahid beheshti university of medical sciences, tehran, iranneuroscience research center, institute of neuropharmacology, kerman university of medical sciences kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_3333.html
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