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Iranian Journal of Basic Medical Sciences، جلد ۱۷، شماره ۸، صفحات ۵۹۵-۵۹۹
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عنوان انگلیسی Antimicrobial susceptibility and analysis of macrolide resistance genes in Streptococcus pneumoniae isolated in Hamadan
چکیده انگلیسی مقاله Objective(s): Macrolide resistant Streptococcus pneumoniae pose an emerging problem globally. The aim of this study was to investigate the prevalence of ermB and mefA genes (macrolide resistant genes) by polymerase chain reaction (PCR) method and to detect drug resistance patterns of S. pneumoniae isolated from clinical samples to macrolides and other antibiotic agents by E-test method. Materials and Methods: Fifty five isolates of S. pneumoniae were obtained from clinical samples with microbial tests. The antibiotic susceptibility of isolates for erythromycin, azithromycin, clarithromycin, ceftazidime, ciprofloxacin and vancomycin were determined by E-test method. Genotypic antibiotic resistance pattern was determined by PCR with primer designed for ermB and mefA genes. Results: The number of S. pneumoniae isolates resistance to erythromycin, azithromycin, clarithromycin, ceftazidim, ciprofloxacin were 25.5%, 18.2%, 16.4%, 21.8% and 10.9%, respectively while no resistance to vancomycin was observed. The macrolide resistance genes of ermB and mefA were found in 10.9% and 18.2% of the isolates, respectively. Conclusion: The result of the current study suggests the necessity of evaluation the changes in MIC[FA1] [a2] (minimum inhibitory concentration) values as well as genetic mutations to estimate the prevalence of the resistance antimicrobial agents in S. pneumoniae.
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نویسندگان مقاله محمد نجفی مصلح | mohammad najafi mosleh
department of microbiology, faculty of medicine, hamadan university of medical sciences, hamadan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

مرضیه غریبی | marzieh gharibi
department of microbiology, faculty of medicine, hamadan university of medical sciences, hamadan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

محمد یوسف علیخانی | mohammad yousef alikhani
department of microbiology, faculty of medicine, hamadan university of medical sciences, hamadan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

مسعود سعیدی جم | massoud saidijam
department of molecular medicine and genetics, hamadan university of medical sciences, hamadan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

فایزه vakhshiteh | faezeh vakhshiteh
human and animal cell bank, iranian biological resource center ibrc , acecr, tehran, iran
نشانی اینترنتی http://ijbms.mums.ac.ir/article_3193.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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