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Iranian Journal of Basic Medical Sciences، جلد ۱۷، شماره ۸، صفحات ۶۰۰-۶۰۵
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عنوان انگلیسی Increased litter size and suckling intensity inhibit KiSS-1 mRNA expression in rat arcuate nucleus
چکیده انگلیسی مقاله Objective(s): The effect of litter size and suckling intensity on the expression of KiSS-1 mRNA in the arcuate nucleus (ARC) of rats were evaluated. Materials and Methods: Thirty two pregnant and four non-lactating ovariectomized (as control group) rats were used in this experiment. Lactating rats were allotted to eight equal groups. In three groups, litter size was adjusted to 5, 10, or 15 pups upon parturition and allowed to suckle their pups continuously by 8 days postpartum. In the other three groups, litter size was adjusted to five upon birth; the pups were separated from the dams for 6 hr on day 8 postpartum, after which the pups were allowed to suckle their dams for 2.5, 5, or 7.5 min prior to killing the dams. Two groups of lactating rats with either 10 or 15 pups were separated from their pups for 6 hr on day 8 postpartum, after which the pups were allowed to suckle their dams for 5 min before the dams were killed on day 8 postpartum. The ARC was removed and the expression of KiSS-1 mRNA was evaluated, using real-time PCR. Results: The expression of KiSS-1 mRNA in the ARC was decreased as the litter size and intensity of suckling stimulus were increased. The effect of suckling intensity on the expression of KiSS-1 mRNA was more pronounced than that of litter size. Conclusion: Increased litter size and suckling intensity decreased KiSS-1 mRNA expression in the ARC which may contribute to lactation anestrus in rat.
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نویسندگان مقاله عاطفه نوروزی | atefeh noroozi
department of animal sciences, college of agriculture, shiraz university, shiraz, iran

سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)

محمدرضا جعفرزاده شیرازی | mohammad reza jafarzadeh shirazi
department of animal sciences, college of agriculture, shiraz university, shiraz, iran

سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)

محمد جواد ضمیری | mohammad javad zamiri
department of animal sciences, college of agriculture, shiraz university, shiraz, iran

سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)

امین تمدن | amin tamadon
infertility research center, shiraz university of medical sciences, shiraz, iran transgenic technology research center, shiraz university of medical sciences, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

امیر اخلاقی | amir akhlaghi
department of animal sciences, college of agriculture, shiraz university, shiraz, iran

سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)

نادر تنیده | nader tanideh
department of pharmacology, school of medicine, shiraz university of medical sciences, shiraz, iran biotechnology institute, college of agriculture, shiraz university, shiraz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

علی مقدم | ali moghadam
biotechnology institute, college of agriculture, shiraz university, shiraz, iran

سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)

علی نیازی | ali niazi
biotechnology institute, college of agriculture, shiraz university, shiraz, iran

سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_3194.html
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