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Iranian Journal of Basic Medical Sciences، جلد ۱۷، شماره ۸، صفحات ۶۲۲-۶۲۵
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عنوان انگلیسی Effect of Scurrula atropurpurea on nitric oxide, endothelial damage, and endothelial progenitor cells of DOCA-salt hypertensive rats
چکیده انگلیسی مقاله Objective(s):To know whether Scurrula atropurpurea is able to modulate total plasma nitrate/nitrite levels, decrease endothelial damage, and increase endothelial progenitor cells (EPCs) in hypertensive rats. Materials and Methods: The rats were divided in 5 groups: control (normotensive) group, Desoxy cortico sterone (DOCA)-salt hypertensive group, and three DOCA-salt hypertensive groups. All 5 groups received methanolic extract of S. atropurpurea (MESA) at a dosage of 50; 100; and 200 mg/KgBW. Serum nitric oxide (NO) was assayed by colorimetric. Circulating endothelial cells (CECs) and EPCs were assayed using flow cytometry. Results: The administration of MESA100 and MESA200 elevated the total plasma nitrate/nitrite levels but cannot reach the level in control group. MESA100 and MESA200 also elevated the EPCs number compared with hypertensive group. The administration of MESA significantly (P< 0.05) decreased the CECs number compared to hypertensive groups. Conclusion: Methanolic extract of S. atropurpurea is able to modulate total plasma nitrate/nitrite levels and diminish endothelial damage via increasing EPCs.
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نویسندگان مقاله نور athiroh | nour athiroh
department of biology, faculty of mathematic and natural sciences, islamic university of malang, malang, east java, indonesia


نور permatasari | nur permatasari
department of pharmacology, faculty of medicine university of brawijaya, malang, east java, indonesia


djanggan sargowo | djanggan sargowo
department of cardiology and vascular medicine, saiful anwar general hospital, faculty of medicine, university of brawijaya, malang, east java, indonesia


m آریس widodo | m aris widodo
department of pharmacology, faculty of medicine university of brawijaya, malang, east java, indonesia
نشانی اینترنتی http://ijbms.mums.ac.ir/article_3197.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Short Communications
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