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Iranian Journal of Basic Medical Sciences، جلد ۱۷، شماره ۷، صفحات ۵۴۱-۵۴۵

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عنوان انگلیسی The effects of Eucheuma cottonii on alveolar macrophages and malondialdehyde levels in bronchoalveolar lavage fluid in chronically particulate matter 10 coal dust-exposed rats
چکیده انگلیسی مقاله Objective(s):To investigate the effect of Eucheuma cottonii on alveolar macrophages (AM) and malondialdehyde (MDA) levels in bronchoalveolar lavage fluids (BALF) in particulate matter 10 (PM10) coal dust-exposed rats. Materials and Methods: Ten groups, including a non exposed group and groups exposed to coal dust at doses of 6.25 (CD6.25), 12.5 (CD12.5), or 25 mg/m3 (CD25) an hour daily for 6 months with or without supplementation of ethanolic extract of E. cottonii at doses of 150 (EC150) or 300 mg/kg BW (EC300). The number of macrophages was determined using a light microscope. MDA levels were measured by TBARS assay. Results: EC150 insignificantly (P > 0.05) reduces the AM in CD groups compared to non treatment groups. EC150 and EC300 significantly (P < 0.05) decreased MDA levels in CD12.5 and CD25 groups relative to non treatment groups. Conclusion: E. cottonii attenuated oxidative stress in chronic exposure of PM10 coal dust.
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نویسندگان مقاله romadhiyana kisno saputri kisno saputri | romadhiyana kisno saputri kisno saputri
faculty of medicine, brawijaya university, malang, east java, indonesia


bambang setiawan | bambang setiawan
department of medical chemistry and biochemistry, research center for toxicology, cancer and degenerative disease, medical faculty, lambung mangkurat university, banjarmasin, south kalimantan, indonesia


دیان nugrahenny | dian nugrahenny
laboratory of pharmacology, faculty of medicine, brawijaya university, malang, east java, indonesia


نیا kania | nia kania
department of pathology, research center for toxicology, cancer and degenerative disease, ulin general hospital, medical faculty, lambung mangkurat university, banjarmasin, south kalimantan, indonesia


endang sri wahyuni | endang sri wahyuni
laboratory of physiology; faculty of medicine, brawijaya university, malang, east java, indonesia


m آریس widodo | m aris widodo
laboratory of pharmacology, faculty of medicine, brawijaya university, malang, east java, indonesia



نشانی اینترنتی http://ijbms.mums.ac.ir/article_3035.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Short Communications
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