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Iranian Journal of Basic Medical Sciences، جلد ۱۷، شماره ۶، صفحات ۴۱۱-۴۱۸
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عنوان انگلیسی The effects of nano-silver and garlic administration during pregnancy on neuron apoptosis in rat offspring hippocampus
چکیده انگلیسی مقاله Objective(s):The aim of this study was to investigate the effects of nano-silver and garlic administration during pregnancy on neuron apoptosis in rat offspring hippocampus. Materials and Methods: Fifty pregnant wistar rats were randomly divided into five groups: 1- nano- silver (N.S) group; 30 mg/kg of N.S treated via gavage. 2- Control (C) group, administrated with distilled water via gavage. 3- N.S and garlic (N.S+G) group; N.S (30 mg/kg) and garlic juice (1 ml/100 g) treated via gavage simultaneously. 4- Garlic group (G); garlic juice (1 ml/100 g) administrated via gavage, 5- normal (N) without any intervention. All the interventions were done during pregnancy (21 days). Finally, the brains of rat offspring were removed to use for nano-silver level measurement and TUNEL staining. The mean of TUNEL positive cell numbers per unit area (NA) in different regions of hippocampus were compared in all animal groups. Results: The results revealed a significant increase of hippocampus nano-silver level in N.S and N.S+G groups comparing to N group (P< 0.05) and a significant decrease in nano-silver level in N.S+G group comparing to N.S group (P< 0.01). The number of TUNEL positive cells in the CA1, CA3, and DG fields of rat offspring hippocampus increased in N.S and N.S+G groups comparing to other ones, and also reduced significantly in N.S+G group comparing to N.S group (¥ P< 0.01). Conclusion: Our results showed that co-administration of nano-silver and garlic during pregnancy may lead to reduce nano-silver induced apoptotic cells in their offspring hippocampus.
کلیدواژه‌های انگلیسی مقاله Apoptosis, Garlic, Hippocampus, Nano-silver
نویسندگان مقاله مریم لاله عطایی | maryam lale ataei
department of anatomy and cell biology, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

علیرضا ابراهیم زاده بیدسکان | ali reza ebrahimzadeh bideskan
department of anatomy and cell biology, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_2925.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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