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Iranian Journal of Basic Medical Sciences، جلد ۱۷، شماره ۶، صفحات ۴۶۰-۴۶۴
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عنوان انگلیسی Antioxidant effects of proanthocyanidin from grape seed on hepatic tissue injury in diabetic rats
چکیده انگلیسی مقاله Objective(s):Diabetes plays an important role in the induction of the liver injury. Grape seed proanthocyanidin (GSP) have a wide range of medicinal properties against oxidative stress. In this study we evaluated antioxidant effects of GSP on liver in streptozotocin-induced diabetic rats. Materials and Methods: Thirty male Sprague–Dawley rats were divided into three groups: control, untreated diabetic and diabetic rats treated with GSP. Diabetes was induced in rats by intraperitoneal injection of streptozotocin (50 mg/kg). GSP were administered via oral gavage (200 mg/kg) for 4 weeks. Results: GSP produced significant hepatoprotective effects by decreasing activities of serum aminotransferases and alkaline phosphatase, and decreasing liver malondialdehyde and bilirubin (P< 0.05) levels. It increased liver superoxide dismutase, catalase and glutathione peroxidase activities and albumin level (P< 0.05). Administration of GSP significantly ameliorated structural changes induced in liver of diabetic rats. Conclusion: GSP have protective effects against hepatic tissue injury due to antioxidant properties.
کلیدواژه‌های انگلیسی مقاله Antioxidant enzyme, Diabetes, GSP, Hepatic tissue
نویسندگان مقاله اسرافیل منصوری | esrafil mansouri
department of anatomical sciences, cellular and molecular research center, faculty of medical sciences, jundishapur university of medical sciences, ahvaz, iran


لعیاسادات خورسندی | layasadat khorsandi
department of anatomical sciences, cellular and molecular research center, faculty of medical sciences, jundishapur university of medical sciences, ahvaz, iran


حسنعلی عابدی | hassan ali abedi
department of physiology, faculty of medical sciences, jahrom university of medical sciences, jahrom, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جهرم (Jahrom university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_2932.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Short Communications
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