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Iranian Journal of Basic Medical Sciences، جلد ۱۷، شماره ۵، صفحات ۳۷۰-۳۷۷
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عنوان انگلیسی Mutations in pre-core and basal-core promoter regions of hepatitis B virus in chronic HBV patients from Golestan, Iran
چکیده انگلیسی مقاله Objective(s): It has been reported that the mutation of the pre-core (PC) and basal-core promoter (BCP) may play an important role in the development of HBV-related hepatocellular carcinoma (HCC). In this study the PC and BCP mutations were investigated in chronic HBV patients. Materials and Methods:In this study, 120 chronic HBV patients from Golestan, Northeast of Iran who were not vaccinated against HBV, were recruited from the year 2008 to 2012. HBV-DNA extraction from plasma and PCR were performed and positive PCR products were subjected to automated sequencing. Results:One hundred out of 120 (83.3%) patients were HBeAg negative. Comparison of our nucleotide sequences with reference sequence showed high rate mutation in BCP and PC region (96.66%). Frame shift mutation was found in 78 (65%) of patients in BCP region, among them 8 (6.6%) patients showed mutation in PC region. Conclusion: Our results demonstrated high rate of mutations in BCP and PC regions among HBV chronic patients in Northeast of Iran.
کلیدواژه‌های انگلیسی مقاله BCP mutation, Hepatitis B, Iran, PC mutation
نویسندگان مقاله عبدالوهاب مرادی | abdolvahab moradi
infectious diseases research center, department of microbiology, school of medicine, golestan university of medical sciences, gorgan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

ساره ژند | sareh zhand
infectious diseases research center, department of microbiology, school of medicine, golestan university of medical sciences, gorgan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

امیر قایمی | amir ghaemi
infectious diseases research center, department of microbiology, school of medicine, golestan university of medical sciences, gorgan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

ناعمه جاوید | naeme javid
infectious diseases research center, department of microbiology, school of medicine, golestan university of medical sciences, gorgan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

مسعود بازوری | masoud bazouri
infectious diseases research center, department of microbiology, school of medicine, golestan university of medical sciences, gorgan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

علیجان تبرایی | alijan tabarraei
infectious diseases research center, department of microbiology, school of medicine, golestan university of medical sciences, gorgan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_2787.html
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زبان مقاله منتشر شده en
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