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Iranian Journal of Basic Medical Sciences، جلد ۱۷، شماره ۲، صفحات ۱۳۴-۱۳۷
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عنوان انگلیسی Prenatal sex determination in suspicious cases of X-linked recessive diseases by the amelogenin gene
چکیده انگلیسی مقاله Objective(s):To determine the fetal discernment in suspected cases of sex linked recessive disease in the first trimester of pregnancy. Materials and Methods: After collection of 100 Chorionic Villi samples, the DNAs were extracted and baby gender was determined. Meanwhile, after increasing the sensitivity, the system was able to detect the sex of each cell which was obtained by biopsy. Results: Early fetal gender of 100 Chorionic Villi samples were assessed by PCR. After increasing sensitivity of the assay, the sexes in 13 fetuses that were in different cellular stages were detected. Morover, sexes were detected in two unfertilized and one fertilized ovum but without any division. Conclusion: Sex detection of fetus before delivery in the first trimester of pregnancy, will prevent babies with abnormalities being born. It can also be used in detection of recessive sex related diseases in In Vitro Fertilization cases for sex detection and to transfer female fetus to the mother. Our optimized molecular detection system was designed on the basis of amelogenin gene, which can determine the sex in blood, chorionic villi, and single cell in vitro fertilization with high sensitivity and specificity.
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نویسندگان مقاله امیر عباس رحیمی | amir abbas rahimi
molecular medicine department, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

محمد حسن شاه حسینی | mohammad hassan shahhosseiny
department of microbiology, islamic azad university, shahr-e- qods branch, tehran, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

قاسم آهنگری | ghasem ahangari
medical biotechnology department, national institute of genetic engineering and biotechnology, tehran, iran

سازمان اصلی تایید شده: پژوهشگاه ملی مهندسی ژنتیک و زیست فناوری

جلال ایزدی مبارکه | jalal izadi mobarakeh
department of pharmacology, tehran medical science branch, islamic azad university, tehran, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_2247.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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